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Chemotherapy Definitions and Policies for Thymic Malignancies

Chemotherapy Definitions and Policies for Thymic Malignancies ITMIG DEFINITIONS AND POLICIES Chemotherapy Definitions and Policies for Thymic Malignancies Nicolas Girard, MD,* Rohit Lal, MD,† Heather Wakelee, MD,‡ Gregory J. Riely, MD,§ and Patrick J. Loehrer, MD Key Words: Thymoma, Thymic carcinoma, Chemotherapy, Radio- Adoption of a common language and definition of therapy, Thymic hyperplasia, Corticosteroids, Octreotide. terms is crucial for the International Thymic Malignancies Interest Group (ITMIG) effort to develop a international (J Thorac Oncol. 2011;6: S1749–S1755) prospective database of thymic tumors. The article by Huang et al. provides definitions for survival and endpoints for recurrences assessment and discusses how to measure re- hymic malignancies are rare epithelial tumors that may be sponse to treatment. Herein, we discuss additional points with Taggressive and difficult to treat. Thymomas are usually regard to chemotherapy, including treatment sequence, gen- localized to the anterior mediastinum and are frequently eral modalities, and impact of corticosteroids. eligible for upfront surgical resection, which is the mainstay of the curative-intent treatment. However, approximately METHODS 30% of patients present with an advanced tumor at the time This article represents a broad consensus within the of diagnosis, with invasion of neighboring organs, dissemi- ITMIG community, based on available underlying evi- nation to the pleura, the pericardium, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Thoracic Oncology Wolters Kluwer Health

Chemotherapy Definitions and Policies for Thymic Malignancies

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ISSN
1556-0864

Abstract

ITMIG DEFINITIONS AND POLICIES Chemotherapy Definitions and Policies for Thymic Malignancies Nicolas Girard, MD,* Rohit Lal, MD,† Heather Wakelee, MD,‡ Gregory J. Riely, MD,§ and Patrick J. Loehrer, MD Key Words: Thymoma, Thymic carcinoma, Chemotherapy, Radio- Adoption of a common language and definition of therapy, Thymic hyperplasia, Corticosteroids, Octreotide. terms is crucial for the International Thymic Malignancies Interest Group (ITMIG) effort to develop a international (J Thorac Oncol. 2011;6: S1749–S1755) prospective database of thymic tumors. The article by Huang et al. provides definitions for survival and endpoints for recurrences assessment and discusses how to measure re- hymic malignancies are rare epithelial tumors that may be sponse to treatment. Herein, we discuss additional points with Taggressive and difficult to treat. Thymomas are usually regard to chemotherapy, including treatment sequence, gen- localized to the anterior mediastinum and are frequently eral modalities, and impact of corticosteroids. eligible for upfront surgical resection, which is the mainstay of the curative-intent treatment. However, approximately METHODS 30% of patients present with an advanced tumor at the time This article represents a broad consensus within the of diagnosis, with invasion of neighboring organs, dissemi- ITMIG community, based on available underlying evi- nation to the pleura, the pericardium,

Journal

Journal of Thoracic OncologyWolters Kluwer Health

Published: Jul 1, 2011

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