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ORIGINAL ARTICLE Angiogenic Markers Show High Prognostic Impact on Survival in Marginally Operable Non-small Cell Lung Cancer Patients Treated with Adjuvant Radiotherapy Sigve Andersen, MD,*† Tom Donnem, MD,*† Samer Al-Saad, MD,‡§ Khalid Al-Shibli, MD,‡ Lill-Tove Busund, MD, PhD,‡§ and Roy M. Bremnes, MD, PhD*† ung cancer is the leading cause of cancer-related deaths Introduction: Protein expressions of angiogenic markers provide Lworld-wide and non-small cell lung cancer (NSCLC) prognostic information on patients with non-small cell lung cancer accounts for approximately 80% of all lung cancer cases. (NSCLC). Both expression and its prognostic impact may be asso- Despite extensive efforts over the last decades, current treat- ciated with patient selection. Data addressing the prognostic rele- ment modalities have only marginally improved survival vance of angiogenic marker expression in NSCLC patients treated rates. Angiogenesis is considered a hallmark of cancer de- with postoperative radiotherapy (PORT) is warranted. velopment as tumor growth requires neovascularization to Methods: In 55 patients with stage I-IIIA NSCLC administered grow beyond a diameter of 2 mm. Angiogenesis is facilitated PORT between 1990 and 2005, we have reviewed the clinicopath- through secretion of ligands acting in an autocrine and paracrine ological variables and investigated the expression of angiogenic manner
Journal of Thoracic Oncology – Wolters Kluwer Health
Published: Apr 1, 2009
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