ABBREVIATIONSCHIKVchikungunya virusCtcycle thresholdDENVdengue virusICinternal controlISinternational standardLODlimit of detectionMMx‐R2master mix reagent 2UCUtility ChannelWNVWest Nile virusZIKVZika virusZika virus (ZIKV) is a flavivirus isolated in 1947 from a rhesus monkey in the Zika forest in Uganda and was identified in humans in 1952. Approximately 80% of the ZIKV infections remain asymptomatic or subclinical. The symptoms are usually nonspecific and include fever, rash, musculoskeletal pain, headache, and conjunctivitis. ZIKV infection of the central nervous system can present as meningoencephalitis. A major concern is the association of ZIKV infection with Guillain‐Barré syndrome in adults and microcephaly and other neurologic manifestations in fetuses of infected mothers.ZIKV is primarily transmitted to humans by the bite of an infected Aedes species mosquito (Ae. aegypti and Ae. albopictus). Other transmission routes are possible, including sexual, mother‐to‐child, and transfusion‐derived transmission. The potential of ZIKV transmission through blood transfusion was demonstrated during the 2013 to 2014 outbreak in French Polynesia when 2.8% of asymptomatic blood donors tested positive for ZIKV RNA. In addition, in Brazil where the first cases of ZIKV appeared in May 2015, two probable cases of transfusion‐transmitted ZIKV were reported. ZIKV phylogenetic analyses demonstrated the existence of two main lineages, the African and the Asian lineage, and
Transfusion – Wiley
Published: Jan 1, 2018
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