Abstract— The substituted benzamide derivative zacopride was found to antagonize competitively the effects of 5‐hydroxytryptamine (5‐HT) on the guinea‐pig ileum, the rabbit vagus nerve and the von Bezold Jarisch reflex in the rat. The potency of zacopride was comparable with that of ICS 205–930 and it is concluded that zacopride possesses 5‐HT3 receptor antagonizing properties.
Journal of Pharmacy and Pharmacology: An International Journal of Pharmaceutical Science – Wiley
Published: Apr 1, 1988
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