Access the full text.
Sign up today, get DeepDyve free for 14 days.
Müller (1987)
Y-190, a DNA probe for the sensitive detection of Y-derived marker chromosomes and mosaicismHum Genet, 75
M. Tsukahara, A. Yoshida (1989)
Chromosomal assignment of the alcohol dehydrogenase cluster locus to human chromosome 4q21-23 by in situ hybridization.Genomics, 4 2
C. Cooper, J. Crolla, C. Laister, D. Johnston, P. Cooke (1991)
An investigation of ring and dicentric chromosomes found in three Turner's syndrome patients using DNA analysis and in situ hybridisation with X and Y chromosome specific probes.Journal of Medical Genetics, 28
D. Callen, H. Eyre, M. Ringenbergs, C. Freemantle, P. Woodroffe, E. Haan (1991)
Chromosomal origin of small ring marker chromosomes in man: characterization by molecular genetics.American journal of human genetics, 48 4
C. Lin, Juliane Meyne, R. Sasi, Peter Bowen, T. Unger, T. Tainaka, Teresa Hadro, Joe Hoo (1990)
Determining the origins and the structural aberrations of small marker chromosomes in two cases of 45,X/46,X, + mar by use of chromosome-specific DNA probes.American journal of medical genetics, 37 1
N. Blin, D. Stafford (1976)
A general method for isolation of high molecular weight DNA from eukaryotes.Nucleic acids research, 3 9
M. Tsukahara, S. Matsuura, F. Kishi, A. Yoshida, T. Kajii (1990)
Isolation of A Y chromosomal DNA sequence and its clinical applicationJapanese Journal of Human Genetics, 35
Andrew Sinclair, P. Berta, Mark Palmer, J. Hawkins, Beatrice Griffiths, Matthijs Smith, J. Foster, A. Frischauf, R. Lovell-Badge, Peter Goodfellow (1990)
A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motifNature, 346
(1989)
4q21-23 by in siru hybridization
R. Scully (1970)
Gonadoblastoma. A review of 74 casesCancer, 25
A 10-year-old girl and a 10-month-old girl, both with ambiguous genitalia, were found to have 45,X/46,X,mar and 45,X/46,X,r(?) mosaicism. The marker chromosomes in both girls were very small. Polymerase chain reaction, with synthetic oligonucleotide primers from Y-specific DNA sequences pY-80 and pY53.3 containing the sex-determining region Y(SRY), proved the marker chromosomes to contain the Y short arm material. In situ hybridization with probe pY-80 confirmed that the marker chromosomes included the Y short arms. These findings, together with ambiguous genitalia in the girls, indicate that the marker chromosomes include the testis-determining factor gene.
Clinical Genetics – Wiley
Published: Aug 1, 1992
Keywords: in situ hybridization; marker chromosome; polymerase chain reaction; Y-specific DNA sequences
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.