Xenopus cadherins: Sorting out types and functions in embryogenesis

Xenopus cadherins: Sorting out types and functions in embryogenesis MICHAEL KUHL AND DORIS WEDLICH Department of Biochemistry, University of Ulm, 0-89081Ulm, Germany. Key words: Cadherin, Catenin, wnt Signalling, cells of different fates (Townes and Holtfreter, 1955). Axis formation, Cell movement, Com- Today, the molecular basis of this process is explained by cadherin function. The amphibian embryo appears munity effect again as the most promising system for gaining insight INTRODUCTION into the molecular interaction between cellular adheCadherins form a superfamily of transmembrane sion and the differentiation of dorsal structures. Sigglycoproteins that are responsible for Ca2+-dependent naling pathways activated by molecules of the wnt cell-cell adhesion. Initially identified in vertebrates, family, which represent the vertebrate homologs of the cadherins have recently also been observed in inverte- segment polarity gene wingless in Drosophila, are coubrates, e.g., Drosophila and Caenorhabditis elegans pled to the cadherin adhesion system by sharing a com(Sano et al., 1993; Oda et al., 1994). This supports the mon mediator protein, P-catenin (Peifer et al., 1993; idea of cadherins as an evolutionarily conserved adhe- Gumbiner, 1995). Both wnt signaling and cadherinsion principle (Pouliot, 1992; Grunwald, 1993). De- mediated adhesion have been successfully investigated pending on the conserved sequence motifs, the follow- in Xenopus embryos, which offer experimental aping http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Developmental Dynamics Wiley

Xenopus cadherins: Sorting out types and functions in embryogenesis

Developmental Dynamics, Volume 207 (2) – Oct 1, 1996

Loading next page...
 
/lp/wiley/xenopus-cadherins-sorting-out-types-and-functions-in-embryogenesis-BMZOlW6Y0n
Publisher
Wiley
Copyright
Copyright © 1996 Wiley‐Liss, Inc.
ISSN
1058-8388
eISSN
1097-0177
DOI
10.1002/(SICI)1097-0177(199610)207:2<121::AID-AJA1>3.0.CO;2-J
pmid
8906416
Publisher site
See Article on Publisher Site

Abstract

MICHAEL KUHL AND DORIS WEDLICH Department of Biochemistry, University of Ulm, 0-89081Ulm, Germany. Key words: Cadherin, Catenin, wnt Signalling, cells of different fates (Townes and Holtfreter, 1955). Axis formation, Cell movement, Com- Today, the molecular basis of this process is explained by cadherin function. The amphibian embryo appears munity effect again as the most promising system for gaining insight INTRODUCTION into the molecular interaction between cellular adheCadherins form a superfamily of transmembrane sion and the differentiation of dorsal structures. Sigglycoproteins that are responsible for Ca2+-dependent naling pathways activated by molecules of the wnt cell-cell adhesion. Initially identified in vertebrates, family, which represent the vertebrate homologs of the cadherins have recently also been observed in inverte- segment polarity gene wingless in Drosophila, are coubrates, e.g., Drosophila and Caenorhabditis elegans pled to the cadherin adhesion system by sharing a com(Sano et al., 1993; Oda et al., 1994). This supports the mon mediator protein, P-catenin (Peifer et al., 1993; idea of cadherins as an evolutionarily conserved adhe- Gumbiner, 1995). Both wnt signaling and cadherinsion principle (Pouliot, 1992; Grunwald, 1993). De- mediated adhesion have been successfully investigated pending on the conserved sequence motifs, the follow- in Xenopus embryos, which offer experimental aping

Journal

Developmental DynamicsWiley

Published: Oct 1, 1996

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off