Wound healing activity of Streptocaulon juventas root ethanolic extract

Wound healing activity of Streptocaulon juventas root ethanolic extract Streptocaulon juventas is a well‐known plant that has antimicrobial activity, in vitro antiplasmodial activity, anti‐proliferative activity, and antioxidant activity. In this study, we showed experimental evidence that proved that S. juventas root ethanolic extract has wound healing activities. First, in a mouse excision wound model, S. juventas root ethanolic extract at a dose of 100 mg/kg/day significantly reduced the wound closure time. After 7 days, the wound granulation tissue in mice treated with the extract exhibited a 2.3‐fold decrease in inflammatory cells, a 1.7‐fold increase in fibroblasts and enhanced angiogenesis. Molecular analysis also revealed that after wounds were treated with S. juventas root ethanolic extract, TNF‐α and NF‐κB1 gene expression were down‐regulated by 4.7 and 3.7 times, respectively. In contrast, TGF‐β1 and VEGF gene expression were up‐regulated by 1.9 and 6.5 times, respectively. Taken together, our experimental data strongly show that the ethanolic extract from S. juventas root displays remarkable wound healing activity. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Wound Repair and Regeneration Wiley

Wound healing activity of Streptocaulon juventas root ethanolic extract

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2017 by the Wound Healing Society
ISSN
1067-1927
eISSN
1524-475X
D.O.I.
10.1111/wrr.12599
Publisher site
See Article on Publisher Site

Abstract

Streptocaulon juventas is a well‐known plant that has antimicrobial activity, in vitro antiplasmodial activity, anti‐proliferative activity, and antioxidant activity. In this study, we showed experimental evidence that proved that S. juventas root ethanolic extract has wound healing activities. First, in a mouse excision wound model, S. juventas root ethanolic extract at a dose of 100 mg/kg/day significantly reduced the wound closure time. After 7 days, the wound granulation tissue in mice treated with the extract exhibited a 2.3‐fold decrease in inflammatory cells, a 1.7‐fold increase in fibroblasts and enhanced angiogenesis. Molecular analysis also revealed that after wounds were treated with S. juventas root ethanolic extract, TNF‐α and NF‐κB1 gene expression were down‐regulated by 4.7 and 3.7 times, respectively. In contrast, TGF‐β1 and VEGF gene expression were up‐regulated by 1.9 and 6.5 times, respectively. Taken together, our experimental data strongly show that the ethanolic extract from S. juventas root displays remarkable wound healing activity.

Journal

Wound Repair and RegenerationWiley

Published: Jan 1, 2017

References

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