Why do neuroprotective drugs that are so promising in animals fail in the clinic? An industry perspective

Why do neuroprotective drugs that are so promising in animals fail in the clinic? An industry... 1. No neuroprotective drug has yet been shown to be effective in treating acute ischaemic stroke in the clinic, despite evidence of efficacy in animal models. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical and Experimental Pharmacology and Physiology Wiley

Why do neuroprotective drugs that are so promising in animals fail in the clinic? An industry perspective

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Publisher
Wiley
Copyright
Copyright © 2002 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0305-1870
eISSN
1440-1681
DOI
10.1046/j.1440-1681.2002.03767.x
Publisher site
See Article on Publisher Site

Abstract

1. No neuroprotective drug has yet been shown to be effective in treating acute ischaemic stroke in the clinic, despite evidence of efficacy in animal models.

Journal

Clinical and Experimental Pharmacology and PhysiologyWiley

Published: Nov 1, 2002

Keywords: ; ; ; ; ; ;

References

  • Clinical experiences with excitatory amino acid antagonists
    Muir, KW; Lees, KR
  • Cerebral blood flow and edema following carotid occlusion in the gerbil
    Crockard, A; Bannotti, F; Hunstock, AT; Smith, RD; Harris, RJ; Symon, L
  • Stroke. Volume 1: Pathophysiology, Diagnosis and Management.
    Mohr, JP; Gautier, JC; Hier, D; Stein, RW
  • Assessment of functional impairment following permanent middle cerebral artery occlusion in a non‐human primate species
    Marshall, JWB; Ridley, RM
  • NXY‐059, a free radical trapping agent, substantially lessens the functional disability resulting from cerebral ischemia in a primate species
    Marshall, JWB; Duffin, KJ; Green, AR; Ridley, RM
  • Rodent models of cerebral ischaemia
    Ginsberg, MD; Busto, R
  • Glycine antagonist in neuroprotection for patients with acute stroke: GAIN Americas: A randomized controlled trial
    Sacco, RL; DeRosa, JT; Haley Jr, EC

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