Whey Protein Antigenicity Reduction by Fungal Proteinases and a Pepsin/Pancreatin Combination

Whey Protein Antigenicity Reduction by Fungal Proteinases and a Pepsin/Pancreatin Combination ABSTRACT Whey protein components were hydrolyzed with Corolase 7092™ (peptidases from Aspergillus strains), pepsin and Corolase PP™ (a mixture of pancreatic enzymes), either individually or in combination, in trials to eliminate protein allergenicity. The hydrolysates were characterized by physico‐chemical and by immunological techniques using sera from patients allergic to milk proteins. Enzyme specificity rather than degree of hydrolysis or molecular mass distribution of hydrolysates determined the residual antigenicity of the whey proteins. Ultrafiltration was a prerequisite for obtaining hypoallergenic whey protein hydrolysates. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Food Science Wiley

Whey Protein Antigenicity Reduction by Fungal Proteinases and a Pepsin/Pancreatin Combination

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Publisher
Wiley
Copyright
Copyright © 1995 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0022-1147
eISSN
1750-3841
D.O.I.
10.1111/j.1365-2621.1995.tb05616.x
Publisher site
See Article on Publisher Site

Abstract

ABSTRACT Whey protein components were hydrolyzed with Corolase 7092™ (peptidases from Aspergillus strains), pepsin and Corolase PP™ (a mixture of pancreatic enzymes), either individually or in combination, in trials to eliminate protein allergenicity. The hydrolysates were characterized by physico‐chemical and by immunological techniques using sera from patients allergic to milk proteins. Enzyme specificity rather than degree of hydrolysis or molecular mass distribution of hydrolysates determined the residual antigenicity of the whey proteins. Ultrafiltration was a prerequisite for obtaining hypoallergenic whey protein hydrolysates.

Journal

Journal of Food ScienceWiley

Published: Jan 1, 1995

References

  • Effects of in vitro proteolysis on the allergenicity of major whey proteins
    Asselin, Asselin; Hebert, Hebert; Amiot, Amiot
  • Immunogenicity of a so‐called hypoallergenic formula in at‐risk babies: two case reports
    Businco, Businco; Lucento, Lucento; Arcese, Arcese; Ziruolo, Ziruolo; Cantani, Cantani
  • OPA method modified by use of N,N‐dimethyl‐2‐mercaptoethylammonium chloride as thiol component
    Frister, Frister; Meisel, Meisel; Schlimme, Schlimme
  • Antigenicity and allergenicity of cow milk hydrolysates intended for infant feeding
    Oldaeus, Oldaeus; Björksten, Björksten; Einarsson, Einarsson; Kjellman, Kjellman
  • How allergenic are hypoallergenic infant formulae
    Rugo, Rugo; Wahl, Wahl; Wahn, Wahn

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