What is changed in HBV molecular epidemiology in Italy?

What is changed in HBV molecular epidemiology in Italy? INTRODUCTIONHepatitis B virus (HBV) infection is a global public health problem causing chronic hepatitis, liver cirrhosis and hepatocellular carcinoma (HCC).To date, 10 HBV genotypes have been identified, from A to J, based on a genetic diversity of at least 8% in the viral genome. These genotypes have a distinct geographic distribution worldwide (http://www.who.int/csr/disease/hepatitis/HepatitisB_whocdscsrlyo2002_2.pdf). HBV‐genotype A predominates in Northern Europe and North America, genotypes B and C in central Asia, genotype D in Mediterranean countries, genotype E in sub‐Saharan Africa and in Madagascar, genotype F in South and Central America, genotypes G and H in Mexico and some other countries in Central America and genotypes I and J in Eastern Asia. In particular, genotypes B and C prevails in highly endemic countries where perinatal HBV transmission plays an important role, whereas genotype A is frequent in areas with primarily horizontal transmission (ie, sexual contact). All genotypes are present in countries of immigration with frequencies depending on the ethnicity.A brief summary on the usefulness of serum makers during HBV infectionPresence of hepatitis B surface antigen (HBsAg) in serum indicates an ongoing HBV infection, acute, or chronic. The serum titre of anti‐HBc IgM (antibody to Hepatitis B core antigen‐HBcAg) may help to http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Medical Virology Wiley

Loading next page...
 
/lp/wiley/what-is-changed-in-hbv-molecular-epidemiology-in-italy-y9pEPGeKWk
Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 Wiley Periodicals, Inc.
ISSN
0146-6615
eISSN
1096-9071
D.O.I.
10.1002/jmv.25027
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONHepatitis B virus (HBV) infection is a global public health problem causing chronic hepatitis, liver cirrhosis and hepatocellular carcinoma (HCC).To date, 10 HBV genotypes have been identified, from A to J, based on a genetic diversity of at least 8% in the viral genome. These genotypes have a distinct geographic distribution worldwide (http://www.who.int/csr/disease/hepatitis/HepatitisB_whocdscsrlyo2002_2.pdf). HBV‐genotype A predominates in Northern Europe and North America, genotypes B and C in central Asia, genotype D in Mediterranean countries, genotype E in sub‐Saharan Africa and in Madagascar, genotype F in South and Central America, genotypes G and H in Mexico and some other countries in Central America and genotypes I and J in Eastern Asia. In particular, genotypes B and C prevails in highly endemic countries where perinatal HBV transmission plays an important role, whereas genotype A is frequent in areas with primarily horizontal transmission (ie, sexual contact). All genotypes are present in countries of immigration with frequencies depending on the ethnicity.A brief summary on the usefulness of serum makers during HBV infectionPresence of hepatitis B surface antigen (HBsAg) in serum indicates an ongoing HBV infection, acute, or chronic. The serum titre of anti‐HBc IgM (antibody to Hepatitis B core antigen‐HBcAg) may help to

Journal

Journal of Medical VirologyWiley

Published: Jan 1, 2018

Keywords: ; ;

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches

$49/month

Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

$588

$360/year

billed annually
Start Free Trial

14-day Free Trial