Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Vertebrate head induction by anterior primitive endoderm

Vertebrate head induction by anterior primitive endoderm In vertebrates the antero‐posterior organization of the embryonic body axis is thought to result from the activity of two separate centers, the head organizer and the trunk organizer, as operationally defined by Spemann in the 1920s. Current molecular studies have supported the existence of a trunk organizer activity while the presence of a distinct head inducing center has remained elusive. Mainly based on analyses of headless mutants in mice, it has been proposed that the anterior axial mesoderm plays a determining role in head induction. Recent gain‐ and loss‐of‐function studies in various organisms, however, provide compelling evidence that a largely ignored region, the anterior primitive endoderm, specifies rostral identity. In this review we discuss the emerging concept that the anterior primitive endoderm, rather than the prechordal plate mesoderm, induces head development in the vertebrate embryo. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png BioEssays Wiley

Vertebrate head induction by anterior primitive endoderm

BioEssays , Volume 19 (10) – Oct 1, 1997

Loading next page...
 
/lp/wiley/vertebrate-head-induction-by-anterior-primitive-endoderm-LxBiPJq6z0

References (81)

Publisher
Wiley
Copyright
Copyright © 1997 Cambridge University Press
ISSN
0265-9247
eISSN
1521-1878
DOI
10.1002/bies.950191005
pmid
9363679
Publisher site
See Article on Publisher Site

Abstract

In vertebrates the antero‐posterior organization of the embryonic body axis is thought to result from the activity of two separate centers, the head organizer and the trunk organizer, as operationally defined by Spemann in the 1920s. Current molecular studies have supported the existence of a trunk organizer activity while the presence of a distinct head inducing center has remained elusive. Mainly based on analyses of headless mutants in mice, it has been proposed that the anterior axial mesoderm plays a determining role in head induction. Recent gain‐ and loss‐of‐function studies in various organisms, however, provide compelling evidence that a largely ignored region, the anterior primitive endoderm, specifies rostral identity. In this review we discuss the emerging concept that the anterior primitive endoderm, rather than the prechordal plate mesoderm, induces head development in the vertebrate embryo.

Journal

BioEssaysWiley

Published: Oct 1, 1997

There are no references for this article.