Verrucous epidermal naevus: a misleading diagnosis for 28 years

Verrucous epidermal naevus: a misleading diagnosis for 28 years EditorEpidermal nevi (EN) are hamartomas of the skin that result from mosaic postzygotic mutations. There are several variants of EN, the verrucous epidermal naevus (VEN) being the most common. EN can be further subdivided into epidermolytic and non‐epidermolytic, important as in contrast with non‐epidermolytic EN, epidermolytic EN occurs sporadically (not heritable), and it is not associated with extracutaneous abnormalities. The epidermal naevus syndrome (ENS) is the association of EN with abnormalities in other organ systems, mainly in the central nervous system, skeletal system, eyes and oral cavity.The aim of this paper was to report a case of a verrucous epidermal naevus that affected the nail unit, and was treated as a viral wart for 28 years.A 28‐year‐old Caucasian female patient presented with a history of an asymptomatic verrucous plaque and nail dystrophy of the right thumb since birth. Despite several treatments with multiple therapeutic modalities mainly against viral warts, including imiquimod cream, cryosurgery and keratolytics, there was no change since then. She reported having had a skin biopsy previously with the diagnosis of a viral wart. Close inspection revealed a hyperkeratotic verrucous plaque involving the medial aspect of the second metacarpus and the right thumb including the proximal and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of the European Academy of Dermatology & Venereology Wiley

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2018 European Academy of Dermatology and Venereology
ISSN
0926-9959
eISSN
1468-3083
D.O.I.
10.1111/jdv.14597
Publisher site
See Article on Publisher Site

Abstract

EditorEpidermal nevi (EN) are hamartomas of the skin that result from mosaic postzygotic mutations. There are several variants of EN, the verrucous epidermal naevus (VEN) being the most common. EN can be further subdivided into epidermolytic and non‐epidermolytic, important as in contrast with non‐epidermolytic EN, epidermolytic EN occurs sporadically (not heritable), and it is not associated with extracutaneous abnormalities. The epidermal naevus syndrome (ENS) is the association of EN with abnormalities in other organ systems, mainly in the central nervous system, skeletal system, eyes and oral cavity.The aim of this paper was to report a case of a verrucous epidermal naevus that affected the nail unit, and was treated as a viral wart for 28 years.A 28‐year‐old Caucasian female patient presented with a history of an asymptomatic verrucous plaque and nail dystrophy of the right thumb since birth. Despite several treatments with multiple therapeutic modalities mainly against viral warts, including imiquimod cream, cryosurgery and keratolytics, there was no change since then. She reported having had a skin biopsy previously with the diagnosis of a viral wart. Close inspection revealed a hyperkeratotic verrucous plaque involving the medial aspect of the second metacarpus and the right thumb including the proximal and

Journal

Journal of the European Academy of Dermatology & VenereologyWiley

Published: Jan 1, 2018

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