Vascular endothelial growth factor prolongs survival in a transgenic mouse model of ALS

Vascular endothelial growth factor prolongs survival in a transgenic mouse model of ALS Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease associated with the death of motor neurons in the spinal cord and brainstem. The cause of ALS is unknown and there is no cure. This study demonstrates, for the first time, that vascular endothelial growth factor (VEGF) delays progression of symptoms and prolongs survival in a Cu/Zn superoxide dismutase (SOD1) transgenic mouse model of ALS. These observations suggest that VEGF or related compounds, might be of value in the treatment of ALS patients. Ann Neurol 2004 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Neurology Wiley

Vascular endothelial growth factor prolongs survival in a transgenic mouse model of ALS

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Publisher
Wiley
Copyright
Copyright © 2003 American Neurological Association
ISSN
0364-5134
eISSN
1531-8249
DOI
10.1002/ana.20223
Publisher site
See Article on Publisher Site

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease associated with the death of motor neurons in the spinal cord and brainstem. The cause of ALS is unknown and there is no cure. This study demonstrates, for the first time, that vascular endothelial growth factor (VEGF) delays progression of symptoms and prolongs survival in a Cu/Zn superoxide dismutase (SOD1) transgenic mouse model of ALS. These observations suggest that VEGF or related compounds, might be of value in the treatment of ALS patients. Ann Neurol 2004

Journal

Annals of NeurologyWiley

Published: Oct 1, 2004

References

  • Hypoxic induction of vascular endothelial growth factor is selectively impaired in mice carrying the mutant SOD1 gene
    Murakami, Murakami; Ilieva, Ilieva; Shiote, Shiote
  • The crucial role of caspase‐9 in the disease progression of a transgenic ALS mouse model
    Inoue, Inoue; Tsukita, Tsukita; Iwasato, Iwasato

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