Variation in the vasopressin V1a receptor promoter and expression: implications for inter‐ and intraspecific variation in social behaviour *

Variation in the vasopressin V1a receptor promoter and expression: implications for inter‐ and... Instability in highly repetitive microsatellite DNA located in the regulatory regions of genes may be a major factor producing diversity in both region‐specific gene expression and the resulting phenotypes. Polymorphisms in promoter regions affecting expression of genes involved in regulating behaviour may play a role in generating individual variation in behaviour, including psychopathologies in humans, and probably are also important for the evolution of behaviour. Here we discuss the prairie vole vasopressin V1a receptor gene as a model that may be useful for understanding the evolution of promoter sequences and the relationship between gene sequence, expression and behavioural phenotype. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Neuroscience Wiley

Variation in the vasopressin V1a receptor promoter and expression: implications for inter‐ and intraspecific variation in social behaviour *

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Publisher
Wiley
Copyright
Copyright © 2002 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0953-816X
eISSN
1460-9568
DOI
10.1046/j.1460-9568.2002.02083.x
Publisher site
See Article on Publisher Site

Abstract

Instability in highly repetitive microsatellite DNA located in the regulatory regions of genes may be a major factor producing diversity in both region‐specific gene expression and the resulting phenotypes. Polymorphisms in promoter regions affecting expression of genes involved in regulating behaviour may play a role in generating individual variation in behaviour, including psychopathologies in humans, and probably are also important for the evolution of behaviour. Here we discuss the prairie vole vasopressin V1a receptor gene as a model that may be useful for understanding the evolution of promoter sequences and the relationship between gene sequence, expression and behavioural phenotype.

Journal

European Journal of NeuroscienceWiley

Published: Aug 1, 2002

References

  • Neuropeptides and the evolution of social behavior
    Insel, Insel; Young, Young
  • Understanding the molecular basis of fragile X syndrome
    Jin, Jin; Warren, Warren
  • Oxytocin and vasopressin receptors and species‐typical social behaviors
    Young, Young
  • Oxytocin and vasopressin as candidate genes for Psychiatric disorders: lessons from animal models
    Young, Young
  • Glutamine repeats and neurodegeneration
    Zoghbi, Zoghbi; Orr, Orr

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