Validation of prognostic scores to predict short‐term mortality in patients with acute‐on‐chronic liver failure

Validation of prognostic scores to predict short‐term mortality in patients with... IntroductionLiver cirrhosis is the 12th leading cause of death worldwide, and liver‐related mortality has remained unchanged for 3 decades despite improvements in general medical care, hepatology care, and post‐liver transplant outcomes. In particular, acute decompensation, which features the acute clinical deterioration of chronic liver disease (CLD), may result in multisystem organ failure and is associated with significant morbidity and mortality. Therefore, to improve prognostication and outcomes in patients with CLD, great efforts have been made to qualify and grade the severity of liver disease. To achieve this goal, a number of prognostic scoring systems have been devised, such as the Child–Pugh score and model for end‐stage liver disease (MELD). However, these scoring systems may provide inaccurate prognostic information in the setting of acute critical illness. Therefore, there is a growing need to develop a novel prognostic scoring system that is appropriate for the acute critical setting of chronic liver disease.Acute‐on‐chronic liver failure (ACLF) is an increasingly recognized distinct condition that involves acute deterioration of liver function in patients with CLD. The European Association for the Study of the Liver‐chronic liver failure (EASL‐CLIF) consortium defined ACLF as a syndrome characterized by acute decompensation of cirrhosis, organ failure, and high short‐term http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Gastroenterology and Hepatology Wiley

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Publisher
Wiley
Copyright
© 2018 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd
ISSN
0815-9319
eISSN
1440-1746
D.O.I.
10.1111/jgh.13991
Publisher site
See Article on Publisher Site

Abstract

IntroductionLiver cirrhosis is the 12th leading cause of death worldwide, and liver‐related mortality has remained unchanged for 3 decades despite improvements in general medical care, hepatology care, and post‐liver transplant outcomes. In particular, acute decompensation, which features the acute clinical deterioration of chronic liver disease (CLD), may result in multisystem organ failure and is associated with significant morbidity and mortality. Therefore, to improve prognostication and outcomes in patients with CLD, great efforts have been made to qualify and grade the severity of liver disease. To achieve this goal, a number of prognostic scoring systems have been devised, such as the Child–Pugh score and model for end‐stage liver disease (MELD). However, these scoring systems may provide inaccurate prognostic information in the setting of acute critical illness. Therefore, there is a growing need to develop a novel prognostic scoring system that is appropriate for the acute critical setting of chronic liver disease.Acute‐on‐chronic liver failure (ACLF) is an increasingly recognized distinct condition that involves acute deterioration of liver function in patients with CLD. The European Association for the Study of the Liver‐chronic liver failure (EASL‐CLIF) consortium defined ACLF as a syndrome characterized by acute decompensation of cirrhosis, organ failure, and high short‐term

Journal

Journal of Gastroenterology and HepatologyWiley

Published: Jan 1, 2018

Keywords: ; ;

References

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