IntroductionLiver cirrhosis is the 12th leading cause of death worldwide, and liver‐related mortality has remained unchanged for 3 decades despite improvements in general medical care, hepatology care, and post‐liver transplant outcomes. In particular, acute decompensation, which features the acute clinical deterioration of chronic liver disease (CLD), may result in multisystem organ failure and is associated with significant morbidity and mortality. Therefore, to improve prognostication and outcomes in patients with CLD, great efforts have been made to qualify and grade the severity of liver disease. To achieve this goal, a number of prognostic scoring systems have been devised, such as the Child–Pugh score and model for end‐stage liver disease (MELD). However, these scoring systems may provide inaccurate prognostic information in the setting of acute critical illness. Therefore, there is a growing need to develop a novel prognostic scoring system that is appropriate for the acute critical setting of chronic liver disease.Acute‐on‐chronic liver failure (ACLF) is an increasingly recognized distinct condition that involves acute deterioration of liver function in patients with CLD. The European Association for the Study of the Liver‐chronic liver failure (EASL‐CLIF) consortium defined ACLF as a syndrome characterized by acute decompensation of cirrhosis, organ failure, and high short‐term
Journal of Gastroenterology and Hepatology – Wiley
Published: Jan 1, 2018
Keywords: ; ;
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera