AbbreviationsACSacute coronary syndromeCTEcoronary thrombotic eventsDAPTdual‐antiplatelet therapyMACEmajor adverse cardiovascular eventsMACCEmajor adverse cardiac and cerebral eventsMBmajor bleedingNSTEMInon‐ST‐segment elevation myocardial infarctionPCIpercutaneous coronary interventionSTstent thrombosisSTEMIST‐segment elevation myocardial infarctionINTRODUCTIONDual‐antiplatelet therapy (DAPT) with aspirin plus a P2Y12 inhibitor reduces thrombotic complications, but increases bleeding complication, after percutaneous coronary intervention (PCI) . Albeit without a universally recognized tool, current guidelines support weighting long‐term risk for both coronary thrombotic and bleeding events before the selection of DAPT duration .Most ischemic and bleeding risk models after PCI thus far have focused on in‐hospital or short‐term risk, and those focused on long‐term risk after coronary stent implantation have been derived and initially validated only in Western populations, despite their global nature, with the three major ones being: the stent thrombosis (ST) score [developed and internally validated by two randomized trials including the harmonizing outcomes with revascularization and stents in acute myocardial infarction (HORIZONS‐AMI) and acute catheterization and urgent intervention triage strategy (ACUITY) trials]; DAPT score [developed and internally validated by the dual antiplatelet therapy study and externally validated by the patient‐related outcomes with endeavor versus cypher stenting (PROTECT) study]; and PARIS score [developed and internally validated by the patterns of non‐adherence to anti‐platelet regimen in stented patients (PARIS) registry
Catheterization and Cardiovascular Interventions – Wiley
Published: Jan 15, 2018
Keywords: ; ; ; ;
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