Utility of zinc protoporphyrin in management of whole blood donors

Utility of zinc protoporphyrin in management of whole blood donors ABBREVIATIONSZINC studyZPP and Iron in the Netherlands Cohort studyZPPzinc protoporphyrinIn the Netherlands and many other countries, the hemoglobin (Hb) level is measured at each visit before whole blood donation to assess whether the donor is capable of blood donation. When this Hb level is below 7.8 and 8.4 mmol/L (12.5 and 13.5 g/dL) for female and male donors, respectively, the donor will be deferred for donation. Hb concentration is considered a proxy for the iron status of the donor. However, in healthy blood donors Hb does not decline until iron stores are fully depleted. A variable that has been reported to more accurately reflect the imbalance between bone marrow iron needs and supplies is zinc protoporphyrin (ZPP). When there is insufficient iron, zinc instead of iron will be incorporated into protoporphyrin IX in the last step of heme synthesis, leading to the formation of ZPP.It was as early as 1987 when it was found that ZPP formation is an early response to body loss of iron. In a study among 10 voluntary healthy males who were followed for 12 weeks, an unknown amount of blood was drawn repeatedly, causing loss of iron. As a consequence ZPP levels started to http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Transfusion Wiley

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Publisher
Wiley
Copyright
© 2018 AABB
ISSN
0041-1132
eISSN
1537-2995
D.O.I.
10.1111/trf.14480
Publisher site
See Article on Publisher Site

Abstract

ABBREVIATIONSZINC studyZPP and Iron in the Netherlands Cohort studyZPPzinc protoporphyrinIn the Netherlands and many other countries, the hemoglobin (Hb) level is measured at each visit before whole blood donation to assess whether the donor is capable of blood donation. When this Hb level is below 7.8 and 8.4 mmol/L (12.5 and 13.5 g/dL) for female and male donors, respectively, the donor will be deferred for donation. Hb concentration is considered a proxy for the iron status of the donor. However, in healthy blood donors Hb does not decline until iron stores are fully depleted. A variable that has been reported to more accurately reflect the imbalance between bone marrow iron needs and supplies is zinc protoporphyrin (ZPP). When there is insufficient iron, zinc instead of iron will be incorporated into protoporphyrin IX in the last step of heme synthesis, leading to the formation of ZPP.It was as early as 1987 when it was found that ZPP formation is an early response to body loss of iron. In a study among 10 voluntary healthy males who were followed for 12 weeks, an unknown amount of blood was drawn repeatedly, causing loss of iron. As a consequence ZPP levels started to

Journal

TransfusionWiley

Published: Jan 1, 2018

References

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