Using primary tumor volumetry to predict treatment outcome for patients with oropharyngeal cancer who were treated with definitive chemoradiotherapy

Using primary tumor volumetry to predict treatment outcome for patients with oropharyngeal cancer... 1INTRODUCTIONConcurrent chemoradiotherapy (CCRT) is the standard treatment for patients with locoregionally advanced oropharyngeal cancer, resulting in good local control (LC) and organ preservation. For personalized treatment, it is important to predict and classify potentially good treatment responders to reduce treatment‐related morbidity, and to classify potentially poor responders to improve treatment outcomes.For head and neck cancer, larger tumor volumes are related to poor LC and survival. Several studies have suggested that pretreatment tumor volume is superior to TNM stage for treatment outcome clarification in patients with head and neck cancer.Tumor volume changes after radiotherapy (RT) have been studied for several other malignancies and volume reduction is a proposed predictive factor of treatment outcome. However, the relationships between tumor volume change and LC or survival are not well known for patients with head and neck cancers. The use of tumor volumetric analysis during RT is controversial. Some authors have reported that tumor volumetry during RT did not provide additional information to predict RT outcomes. However, if there were an early predictive factor of treatment result, RT could be changed or intensified based on tumor volume change during RT, and adjuvant treatment could be administered after RT, resulting in better tumor control. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Asia-Pacific Journal of Clinical Oncology Wiley

Using primary tumor volumetry to predict treatment outcome for patients with oropharyngeal cancer who were treated with definitive chemoradiotherapy

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2018 John Wiley & Sons Australia, Ltd
ISSN
1743-7555
eISSN
1743-7563
D.O.I.
10.1111/ajco.12704
Publisher site
See Article on Publisher Site

Abstract

1INTRODUCTIONConcurrent chemoradiotherapy (CCRT) is the standard treatment for patients with locoregionally advanced oropharyngeal cancer, resulting in good local control (LC) and organ preservation. For personalized treatment, it is important to predict and classify potentially good treatment responders to reduce treatment‐related morbidity, and to classify potentially poor responders to improve treatment outcomes.For head and neck cancer, larger tumor volumes are related to poor LC and survival. Several studies have suggested that pretreatment tumor volume is superior to TNM stage for treatment outcome clarification in patients with head and neck cancer.Tumor volume changes after radiotherapy (RT) have been studied for several other malignancies and volume reduction is a proposed predictive factor of treatment outcome. However, the relationships between tumor volume change and LC or survival are not well known for patients with head and neck cancers. The use of tumor volumetric analysis during RT is controversial. Some authors have reported that tumor volumetry during RT did not provide additional information to predict RT outcomes. However, if there were an early predictive factor of treatment result, RT could be changed or intensified based on tumor volume change during RT, and adjuvant treatment could be administered after RT, resulting in better tumor control.

Journal

Asia-Pacific Journal of Clinical OncologyWiley

Published: Jan 1, 2018

Keywords: ; ;

References

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