Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Usefulness of B‐mode and doppler sonography for the diagnosis of severe acute viral hepatitis A

Usefulness of B‐mode and doppler sonography for the diagnosis of severe acute viral hepatitis A ABSTRACT Background To investigate B‐mode and Doppler ultrasonography (US) features correlating with laboratory findings for the diagnosis of severe acute hepatitis (SAH) in patients with hepatitis A virus infection. Methods Thirty‐nine consecutive serologically proven patients were enrolled. Decreased parenchymal echotexture, periportal tracking, gallbladder wall change, and splenomegaly were assessed on B‐mode images. Blood flow velocities were measured in the main portal (VPORTAL) and in the hepatic veins, and the hepatic venous pulsatility index was calculated. SAH was defined as high model for end‐stage liver disease (MELD) score ≥15 with or without coagulopathy. The relationship between US features and laboratory findings was assessed, and SAH diagnosis was evaluated. Results Serum alanine transaminase and prothrombin time were significantly different depending on the presence of gallbladder wall change and splenomegaly (p < 0.05). VPORTAL was inversely correlated with MELD score (r = −0.485) and several laboratory markers. The hepatic venous waveform and hepatic venous pulsatility index were significantly correlated with MELD score. For the diagnosis of SAH, the area under the receiver operating characteristic curve of VPORTAL was 0.798. It reached 0.869 in the patients with typical GB change. Conclusions Both B‐mode and Doppler US correlated well with several laboratory variables and may be helpful to diagnose SAH in patients with hepatitis A virus infection. © 2014 Wiley Periodicals, Inc. J Clin Ultrasound 43:384–392, 2015 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Clinical Ultrasound Wiley

Usefulness of B‐mode and doppler sonography for the diagnosis of severe acute viral hepatitis A

Loading next page...
 
/lp/wiley/usefulness-of-b-mode-and-doppler-sonography-for-the-diagnosis-of-x5F1MyjLRR

References (34)

Publisher
Wiley
Copyright
© 2015 Wiley Periodicals, Inc.
ISSN
0091-2751
eISSN
1097-0096
DOI
10.1002/jcu.22234
pmid
25195942
Publisher site
See Article on Publisher Site

Abstract

ABSTRACT Background To investigate B‐mode and Doppler ultrasonography (US) features correlating with laboratory findings for the diagnosis of severe acute hepatitis (SAH) in patients with hepatitis A virus infection. Methods Thirty‐nine consecutive serologically proven patients were enrolled. Decreased parenchymal echotexture, periportal tracking, gallbladder wall change, and splenomegaly were assessed on B‐mode images. Blood flow velocities were measured in the main portal (VPORTAL) and in the hepatic veins, and the hepatic venous pulsatility index was calculated. SAH was defined as high model for end‐stage liver disease (MELD) score ≥15 with or without coagulopathy. The relationship between US features and laboratory findings was assessed, and SAH diagnosis was evaluated. Results Serum alanine transaminase and prothrombin time were significantly different depending on the presence of gallbladder wall change and splenomegaly (p < 0.05). VPORTAL was inversely correlated with MELD score (r = −0.485) and several laboratory markers. The hepatic venous waveform and hepatic venous pulsatility index were significantly correlated with MELD score. For the diagnosis of SAH, the area under the receiver operating characteristic curve of VPORTAL was 0.798. It reached 0.869 in the patients with typical GB change. Conclusions Both B‐mode and Doppler US correlated well with several laboratory variables and may be helpful to diagnose SAH in patients with hepatitis A virus infection. © 2014 Wiley Periodicals, Inc. J Clin Ultrasound 43:384–392, 2015

Journal

Journal of Clinical UltrasoundWiley

Published: Jul 8, 2015

There are no references for this article.