Use of In Vitro Assays in Selection of Compatible Platelet Donors

Use of In Vitro Assays in Selection of Compatible Platelet Donors Although HLA‐matched platelet transfusions are of value in the support of some alloimmunized thrombocytopenic patients, poor posttransfusion increments can be observed following HLA‐matched platelet transfusions and conversely good posttransfusion increments may result after HLA‐mismatched platelet transfusions. We have explored the possibility that in vitro assays in addition to HLA typing might better select compatible donors for refractory recipients. Our studies suggested that a platelet migration inhibition assay is predictive of platelet transfusion responses in HLA‐compatible and incompatible donor‐recipient pairs, while lymphocyto‐toxicity is predictive of posttransfusion increments only in HLA‐incompatible donor‐recipient pairs. Granulocy‐totoxicity, microleukoagglutination, and capillary leu‐koagglutination showed no value in predicting platelet transfusion increments, either in HLA‐compatible or incompatible donor‐recipient pairs. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Transfusion Wiley

Use of In Vitro Assays in Selection of Compatible Platelet Donors

Loading next page...
 
/lp/wiley/use-of-in-vitro-assays-in-selection-of-compatible-platelet-donors-dUWQZ0Esrm
Publisher
Wiley
Copyright
Copyright © 1980 Wiley Subscription Services
ISSN
0041-1132
eISSN
1537-2995
DOI
10.1046/j.1537-2995.1980.20180125040.x
Publisher site
See Article on Publisher Site

Abstract

Although HLA‐matched platelet transfusions are of value in the support of some alloimmunized thrombocytopenic patients, poor posttransfusion increments can be observed following HLA‐matched platelet transfusions and conversely good posttransfusion increments may result after HLA‐mismatched platelet transfusions. We have explored the possibility that in vitro assays in addition to HLA typing might better select compatible donors for refractory recipients. Our studies suggested that a platelet migration inhibition assay is predictive of platelet transfusion responses in HLA‐compatible and incompatible donor‐recipient pairs, while lymphocyto‐toxicity is predictive of posttransfusion increments only in HLA‐incompatible donor‐recipient pairs. Granulocy‐totoxicity, microleukoagglutination, and capillary leu‐koagglutination showed no value in predicting platelet transfusion increments, either in HLA‐compatible or incompatible donor‐recipient pairs.

Journal

TransfusionWiley

Published: Jan 2, 1980

References

  • Platelet migration inhibition: a new method for detection of platelet antibodies
    Lorentzen, DF; Aster, RH
  • A microgranulocyte cytotoxicity test
    Hasegawa, T.; Graw, RG; Terasaki, PI
  • Specific interaction of HLA antibodies (eluates) with washed platelets
    Heinrich, D.; Stephinger, U.; Mueller‐Eckhardt, C.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off