Urine sodium concentrations are predictive of hypoadrenocorticism in hyponatraemic dogs: a retrospective pilot study

Urine sodium concentrations are predictive of hypoadrenocorticism in hyponatraemic dogs: a... INTRODUCTIONClassical primary hypoadrenocorticism is a syndrome that is often challenging to diagnose due to its vague clinical signs and lack of pathognomonic clinicopathologic data. Many dogs with hypoadrenocorticism are critically ill and require expensive care and hospitalisation before a definitive diagnosis is made. Serum cortisol is usually measured by reference laboratories, typically with a waiting period after a sample is collected. Therefore, a test available in an emergency setting that could be used to help to prioritise the differential diagnosis of hypoadrenocorticism in a critically ill patient would have value in providing a tentative prognosis before expensive care and hospitalisation.In classical hypoadrenocorticism, aldosterone deficiency results in renal sodium wasting and potassium retention, resulting in hyponatraemia and hyperkalaemia (Willard et al. , Rakich & Lorenz , Melian & Peterson , Adler et al. , Haviland et al. ). Dogs with classical hypoadrenocorticism become total body volume‐ and sodium‐depleted, which can result in severe neurological and cardiovascular complications (Melian & Peterson , Brady et al. , MacMillan ).In a hypovolaemic hyponatraemic state, the renal tubules should actively resorb sodium, resulting in minimal loss of sodium into the urine (Tyler et al. , Kamel et al. , Fenske et al. , Spasovski http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Small Animal Practice Wiley

Urine sodium concentrations are predictive of hypoadrenocorticism in hyponatraemic dogs: a retrospective pilot study

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 British Small Animal Veterinary Association
ISSN
0022-4510
eISSN
1748-5827
D.O.I.
10.1111/jsap.12792
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONClassical primary hypoadrenocorticism is a syndrome that is often challenging to diagnose due to its vague clinical signs and lack of pathognomonic clinicopathologic data. Many dogs with hypoadrenocorticism are critically ill and require expensive care and hospitalisation before a definitive diagnosis is made. Serum cortisol is usually measured by reference laboratories, typically with a waiting period after a sample is collected. Therefore, a test available in an emergency setting that could be used to help to prioritise the differential diagnosis of hypoadrenocorticism in a critically ill patient would have value in providing a tentative prognosis before expensive care and hospitalisation.In classical hypoadrenocorticism, aldosterone deficiency results in renal sodium wasting and potassium retention, resulting in hyponatraemia and hyperkalaemia (Willard et al. , Rakich & Lorenz , Melian & Peterson , Adler et al. , Haviland et al. ). Dogs with classical hypoadrenocorticism become total body volume‐ and sodium‐depleted, which can result in severe neurological and cardiovascular complications (Melian & Peterson , Brady et al. , MacMillan ).In a hypovolaemic hyponatraemic state, the renal tubules should actively resorb sodium, resulting in minimal loss of sodium into the urine (Tyler et al. , Kamel et al. , Fenske et al. , Spasovski

Journal

Journal of Small Animal PracticeWiley

Published: Jan 1, 2018

References

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