Urinary aquaporin‐2 as a possible objective biomarker of nocturnal polyuria

Urinary aquaporin‐2 as a possible objective biomarker of nocturnal polyuria Nocturnal enuresis (NE) is the involuntary voiding of urine during sleep in the absence of physical disease in children above the age of 5 years. The major causes of NE are urinary bladder dysfunction and nocturnal polyuria (NP). In NP, reduction in the nocturnal level of arginine vasopressin (AVP) leads to a high urine output at night. Desmopressin acetate (DDAVP) is commonly used to treat NP, but not all patients respond to DDAVP. Therefore, a new objective biomarker to reflect AVP secretion during sleep is warranted, to select patients with NE for treatment with DDAVP.Aquaporin 2 (AQP2) is an AVP‐sensitive water channel that mediates transmembrane water transport in the collecting ducts. AQP2 is excreted into the urine, and its excretion increases in response to AVP. Therefore, urinary excretion of AQP2 is proposed to be a biomarker of the responsiveness of the collecting duct to AVP.To investigate whether AQP2 level in morning urine could be used as an objective biomarker of NP, we measured urinary AQP2/creatinine (AQP2/Cr) in 34 NE patients (23 male, 11 female; mean age, 9.6 ± 2.1 years), of whom 28 had NP. NP was defined according to the following Japanese criteria: nocturnal urine volume >0.9 mL/kg/h of sleep or http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pediatrics International Wiley

Urinary aquaporin‐2 as a possible objective biomarker of nocturnal polyuria

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Publisher
Wiley
Copyright
Copyright © 2018 Japan Pediatric Society
ISSN
1328-8067
eISSN
1442-200X
D.O.I.
10.1111/ped.13443
Publisher site
See Article on Publisher Site

Abstract

Nocturnal enuresis (NE) is the involuntary voiding of urine during sleep in the absence of physical disease in children above the age of 5 years. The major causes of NE are urinary bladder dysfunction and nocturnal polyuria (NP). In NP, reduction in the nocturnal level of arginine vasopressin (AVP) leads to a high urine output at night. Desmopressin acetate (DDAVP) is commonly used to treat NP, but not all patients respond to DDAVP. Therefore, a new objective biomarker to reflect AVP secretion during sleep is warranted, to select patients with NE for treatment with DDAVP.Aquaporin 2 (AQP2) is an AVP‐sensitive water channel that mediates transmembrane water transport in the collecting ducts. AQP2 is excreted into the urine, and its excretion increases in response to AVP. Therefore, urinary excretion of AQP2 is proposed to be a biomarker of the responsiveness of the collecting duct to AVP.To investigate whether AQP2 level in morning urine could be used as an objective biomarker of NP, we measured urinary AQP2/creatinine (AQP2/Cr) in 34 NE patients (23 male, 11 female; mean age, 9.6 ± 2.1 years), of whom 28 had NP. NP was defined according to the following Japanese criteria: nocturnal urine volume >0.9 mL/kg/h of sleep or

Journal

Pediatrics InternationalWiley

Published: Jan 1, 2018

Keywords: ; ; ;

References

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