INTRODUCTIONAs a life‐threatening disease, cancer has increasingly been a heavy burden of healthcare system. The failure of cancer therapy and poor outcomes are mostly owing to the development of local invasion and distant metastasis. Activating of invasion and metastasis has been demonstrated as one of the most important hallmark capabilities of cancer. To date, researchers have paid tremendous attention to the biological behaviour of cancer cells, aiming at finding potential therapeutic targets.Invasion and metastasis are considered as complex processes involving detachment of cancer cell from primary tumour site and formation of new tumour foci in distant organs. Epithelial‐mesenchymal transition (EMT), a developmental regulatory programme, identified as transformed epithelial cells loss epithelial constraints and then acquire the abilities to invade, resist apoptosis and metastasis, which is believed to play a vital role in broadly regulating invasion and metastasis. Cadherins are a family of calcium‐dependent glycoproteins, which responsible for Ca2+‐dependent cell‐cell adhesions. Of the members of this family, N‐cadherin (neuronal cadherin or cadherin‐2), a transmembrane glycoprotein, which is normally expressed in neuroectodermal and mesenchymal‐derived tissues, plays crucial role in lots of processes, such as cell‐cell adhesion, embryogenesis, gastrulation, neurulation, migration and invasion. Today, N‐cadherin is regarded as a vital marker of
European Journal of Clinical Investigation – Wiley
Published: Jan 1, 2018
Keywords: ; ; ;
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