Unrelated donor choices for allogeneic hematopoietic cell transplantation in Canada: an evaluation of factors influencing donor selection

Unrelated donor choices for allogeneic hematopoietic cell transplantation in Canada: an... ABBREVIATIONSBMmarrowCBB(s)cord blood bank(s)CBU(s)cord blood unit(s)DLI(s)donor lymphocyte infusion(s)INTinternationalOMOneMatchPBSC(s)peripheral blood stem/progenitor cell(s)TNCtotal nucleated cell countIncreasing numbers of patients are deemed eligible for hematopoietic cell transplantation, including older patients with comorbidities, due to improved supportive care and the introduction of reduced‐intensity conditioning regimens. Moreover, evolving indications for allogeneic transplant include acute myeloid leukemia at earlier stages of disease, myelodysplastic syndrome, and myeloproliferative disorders. As the number of available sibling donors declines due to smaller family size in recent decades and potential issues related to donor eligibility in older siblings, transplant centers continue to rely heavily on unrelated donors and cord blood units (CBUs). Canadian transplant centers typically prefer allele matching of prospective donors at HLA‐A, ‐B, ‐C, ‐DRB1, and ‐DQB1 loci, with the hope of identifying 10 of 10 HLA‐matched donors. While HLA match level between donor/recipient pairs is considered to be the dominant factor in the selection of unrelated donors, the extent to which additional factors such as sex and donor age influence donor choice remains unclear and the impact of patient ethnicity on donor matching in Canada is unknown. While OneMatch (OM) search specialists can assist in allogeneic search strategies, donor selection is ultimately the responsibility of Canadian transplant centers.With http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Transfusion Wiley

Unrelated donor choices for allogeneic hematopoietic cell transplantation in Canada: an evaluation of factors influencing donor selection

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Publisher
Wiley
Copyright
© 2018 AABB
ISSN
0041-1132
eISSN
1537-2995
D.O.I.
10.1111/trf.14458
Publisher site
See Article on Publisher Site

Abstract

ABBREVIATIONSBMmarrowCBB(s)cord blood bank(s)CBU(s)cord blood unit(s)DLI(s)donor lymphocyte infusion(s)INTinternationalOMOneMatchPBSC(s)peripheral blood stem/progenitor cell(s)TNCtotal nucleated cell countIncreasing numbers of patients are deemed eligible for hematopoietic cell transplantation, including older patients with comorbidities, due to improved supportive care and the introduction of reduced‐intensity conditioning regimens. Moreover, evolving indications for allogeneic transplant include acute myeloid leukemia at earlier stages of disease, myelodysplastic syndrome, and myeloproliferative disorders. As the number of available sibling donors declines due to smaller family size in recent decades and potential issues related to donor eligibility in older siblings, transplant centers continue to rely heavily on unrelated donors and cord blood units (CBUs). Canadian transplant centers typically prefer allele matching of prospective donors at HLA‐A, ‐B, ‐C, ‐DRB1, and ‐DQB1 loci, with the hope of identifying 10 of 10 HLA‐matched donors. While HLA match level between donor/recipient pairs is considered to be the dominant factor in the selection of unrelated donors, the extent to which additional factors such as sex and donor age influence donor choice remains unclear and the impact of patient ethnicity on donor matching in Canada is unknown. While OneMatch (OM) search specialists can assist in allogeneic search strategies, donor selection is ultimately the responsibility of Canadian transplant centers.With

Journal

TransfusionWiley

Published: Jan 1, 2018

References

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