Unique profile of antimicrobial peptide expression in polymorphic light eruption lesions compared to healthy skin, atopic dermatitis, and psoriasis

Unique profile of antimicrobial peptide expression in polymorphic light eruption lesions compared... INTRODUCTIONUltraviolet radiation (UVR) results in local and systemic immunosuppression. This seems, on one hand, to be a crucial factor for skin cancer development, on the other, a lack of it might favor the occurrence of the most common photodermatosis polymorphic light eruption (PLE). PLE occurs in roughly 10%‐20% of the population of the Western world, mostly among young women, and is commonly characterized by itchy skin lesions of varying morphology. It usually occurs during spring or early summer upon exposure to sunlight and the symptoms usually subside with repeated sunlight exposure due to continuous natural photo hardening as the summer progresses or after medical photo hardening. The exact etiology and pathogenesis of PLE still remain a mystery; however, resistance to UV‐induced immunosuppression and type IV delayed‐type hypersensitivity (DTH) to photo‐antigens are believed to play a key role in the disease. The physiological occurrence of UV‐induced immunosuppression may protect healthy subjects from symptoms of PLE by suppressing the immune reaction to newly formed (photo) antigens probably due to regulatory T cells, whereas in PLE prone subjects, a failure of immune suppression might favor the occurrence of the skin rash of the disease.Skin cells produce small 10‐50 amino acid residues known http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Photodermatology, Photoimmunology & Photomedicine Wiley

Unique profile of antimicrobial peptide expression in polymorphic light eruption lesions compared to healthy skin, atopic dermatitis, and psoriasis

Loading next page...
 
/lp/wiley/unique-profile-of-antimicrobial-peptide-expression-in-polymorphic-oL9ZKiePJV
Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
ISSN
0905-4383
eISSN
1600-0781
D.O.I.
10.1111/phpp.12355
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONUltraviolet radiation (UVR) results in local and systemic immunosuppression. This seems, on one hand, to be a crucial factor for skin cancer development, on the other, a lack of it might favor the occurrence of the most common photodermatosis polymorphic light eruption (PLE). PLE occurs in roughly 10%‐20% of the population of the Western world, mostly among young women, and is commonly characterized by itchy skin lesions of varying morphology. It usually occurs during spring or early summer upon exposure to sunlight and the symptoms usually subside with repeated sunlight exposure due to continuous natural photo hardening as the summer progresses or after medical photo hardening. The exact etiology and pathogenesis of PLE still remain a mystery; however, resistance to UV‐induced immunosuppression and type IV delayed‐type hypersensitivity (DTH) to photo‐antigens are believed to play a key role in the disease. The physiological occurrence of UV‐induced immunosuppression may protect healthy subjects from symptoms of PLE by suppressing the immune reaction to newly formed (photo) antigens probably due to regulatory T cells, whereas in PLE prone subjects, a failure of immune suppression might favor the occurrence of the skin rash of the disease.Skin cells produce small 10‐50 amino acid residues known

Journal

Photodermatology, Photoimmunology & PhotomedicineWiley

Published: Jan 1, 2018

Keywords: ; ; ; ;

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches

$49/month

Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

$588

$360/year

billed annually
Start Free Trial

14-day Free Trial