INTRODUCTIONUltraviolet radiation (UVR) results in local and systemic immunosuppression. This seems, on one hand, to be a crucial factor for skin cancer development, on the other, a lack of it might favor the occurrence of the most common photodermatosis polymorphic light eruption (PLE). PLE occurs in roughly 10%‐20% of the population of the Western world, mostly among young women, and is commonly characterized by itchy skin lesions of varying morphology. It usually occurs during spring or early summer upon exposure to sunlight and the symptoms usually subside with repeated sunlight exposure due to continuous natural photo hardening as the summer progresses or after medical photo hardening. The exact etiology and pathogenesis of PLE still remain a mystery; however, resistance to UV‐induced immunosuppression and type IV delayed‐type hypersensitivity (DTH) to photo‐antigens are believed to play a key role in the disease. The physiological occurrence of UV‐induced immunosuppression may protect healthy subjects from symptoms of PLE by suppressing the immune reaction to newly formed (photo) antigens probably due to regulatory T cells, whereas in PLE prone subjects, a failure of immune suppression might favor the occurrence of the skin rash of the disease.Skin cells produce small 10‐50 amino acid residues known
Photodermatology, Photoimmunology & Photomedicine – Wiley
Published: Jan 1, 2018
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