INTRODUCTIONUltraviolet radiation (UVR) results in local and systemic immunosuppression. This seems, on one hand, to be a crucial factor for skin cancer development, on the other, a lack of it might favor the occurrence of the most common photodermatosis polymorphic light eruption (PLE). PLE occurs in roughly 10%‐20% of the population of the Western world, mostly among young women, and is commonly characterized by itchy skin lesions of varying morphology. It usually occurs during spring or early summer upon exposure to sunlight and the symptoms usually subside with repeated sunlight exposure due to continuous natural photo hardening as the summer progresses or after medical photo hardening. The exact etiology and pathogenesis of PLE still remain a mystery; however, resistance to UV‐induced immunosuppression and type IV delayed‐type hypersensitivity (DTH) to photo‐antigens are believed to play a key role in the disease. The physiological occurrence of UV‐induced immunosuppression may protect healthy subjects from symptoms of PLE by suppressing the immune reaction to newly formed (photo) antigens probably due to regulatory T cells, whereas in PLE prone subjects, a failure of immune suppression might favor the occurrence of the skin rash of the disease.Skin cells produce small 10‐50 amino acid residues known
Photodermatology, Photoimmunology & Photomedicine – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ;
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.
All for just $49/month
Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.
Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.
It’s easy to organize your research with our built-in tools.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera