Uncoupling of serotonergic and noradrenergic systems in depression: Preliminary evidence from continuous cerebrospinal fluid sampling

Uncoupling of serotonergic and noradrenergic systems in depression: Preliminary evidence from... We used the technique of continuous cerebrospinal fluid (CSF) sampling to test the following hypotheses regarding CNS monoaminergic systems in depression:(1) absolute concentrations of the informational substances tryptophan and 5‐hydroxyindoleacetic acid (5‐HIAA) are altered in the CNS of depressed patients (2) abnormal rhythms of tryptophan and/or 5‐HIAA, or defective conversion of tryptophan to serotonin (5HT), exist in the CNS of depressed patients, and (3) the relationship between the CNS 5HT and norepinephrine (NE) systems is disrupted in depressed patients. We obtained 6‐h concentration time series of tryptophan, 5‐HIAA, NE, and 3‐methoxy‐4‐hydroxyphenylglycol (MHPG) in the CSF of 10 patients with major depression and in 10 normal volunteers. No significant differences in CSF tryptophan, 5‐HIAA, NE, or MHPG concentrations or rhythms were observed between normal volunteers and depressed patients. Neither were there differences in the mean tryptophan‐to‐serotonin ratio. However, a negative linear relationship was observed between mean concentrations of 5‐HIAA and NE in the CSF of the normal volunteers (r = 0.916 (r2 = 0.839), df = 9, P < 0.001) while, in contrast, depressed patients showed no such relationship (r = +0.094 (r2 = 0.00877), df = 9, n.s.). Furthermore, the correlation coefficients expressing the relationship between CSF MHPG and CSF 5‐HIAA within the normal and depressed groups were significantly different. These data support the hypothesis that a disturbance in the interaction between the serotonergic and noradrenergic systems can exist in depressive illness in the absence of any simple 5HT or NE deficit or surplus. Depression and Anxiety 6:89–94, 1997.© 1997 Wiley‐Liss, Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Depression and Anxiety Wiley

Uncoupling of serotonergic and noradrenergic systems in depression: Preliminary evidence from continuous cerebrospinal fluid sampling

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Publisher
Wiley
Copyright
Copyright © 1997 Wiley‐Liss, Inc.
ISSN
1091-4269
eISSN
1520-6394
DOI
10.1002/(SICI)1520-6394(1997)6:3<89::AID-DA1>3.0.CO;2-0
Publisher site
See Article on Publisher Site

Abstract

We used the technique of continuous cerebrospinal fluid (CSF) sampling to test the following hypotheses regarding CNS monoaminergic systems in depression:(1) absolute concentrations of the informational substances tryptophan and 5‐hydroxyindoleacetic acid (5‐HIAA) are altered in the CNS of depressed patients (2) abnormal rhythms of tryptophan and/or 5‐HIAA, or defective conversion of tryptophan to serotonin (5HT), exist in the CNS of depressed patients, and (3) the relationship between the CNS 5HT and norepinephrine (NE) systems is disrupted in depressed patients. We obtained 6‐h concentration time series of tryptophan, 5‐HIAA, NE, and 3‐methoxy‐4‐hydroxyphenylglycol (MHPG) in the CSF of 10 patients with major depression and in 10 normal volunteers. No significant differences in CSF tryptophan, 5‐HIAA, NE, or MHPG concentrations or rhythms were observed between normal volunteers and depressed patients. Neither were there differences in the mean tryptophan‐to‐serotonin ratio. However, a negative linear relationship was observed between mean concentrations of 5‐HIAA and NE in the CSF of the normal volunteers (r = 0.916 (r2 = 0.839), df = 9, P < 0.001) while, in contrast, depressed patients showed no such relationship (r = +0.094 (r2 = 0.00877), df = 9, n.s.). Furthermore, the correlation coefficients expressing the relationship between CSF MHPG and CSF 5‐HIAA within the normal and depressed groups were significantly different. These data support the hypothesis that a disturbance in the interaction between the serotonergic and noradrenergic systems can exist in depressive illness in the absence of any simple 5HT or NE deficit or surplus. Depression and Anxiety 6:89–94, 1997.© 1997 Wiley‐Liss, Inc.

Journal

Depression and AnxietyWiley

Published: Jan 1, 1997

References

  • Clinical investigation of monoamine neurotransmitter interactions
    Hsiao, Hsiao; Potter, Potter; Agren, Agren; Owen, Owen; Pickar, Pickar
  • Role of serotonin in the pathophysiology of depression: Focus on the role of the serotonin transporter
    Owens, Owens; Nemeroff, Nemeroff
  • Catecholamines in depression: An update
    Potter, Potter; Manji, Manji
  • Qualitative and quantitative high performance liquid chromatographic analysis of monoamine neurotransmitters and metabolites in cerebrospinal fluid and brain tissue using reductive electrochemical detection
    Schmidt, Schmidt; Roznoski, Roznoski; Ebert, Ebert

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