Ultrastructural examination of the skeletal muscles in polymyalgia rheumatica

Ultrastructural examination of the skeletal muscles in polymyalgia rheumatica Skeletal muscle biopsies of 13 patients with polymyalgia rheumatica (PMR) were examined systematically with the electron microscope. Ultrastructural changes in the PMR specimens have been classified according to 14 criteria including nucleus, myofilaments, mitochondria, T‐system, as well as glycogen deposition, lipid, lipofuscin, and myelin figures. The described muscle changes are of both regressive and progressive character and non‐specific in themselves. The systematic recording of these criteria shows an extraordinaryly high incidence in PMR. This constellation of characteristics gives the ultrastructural picture of the skeletal musculature in PMR a definite profile. Similarities with the changes in other muscular diseases suggest that in PMR also neurogenous mechanisms may play a pathogenetic role. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Pathology Wiley

Ultrastructural examination of the skeletal muscles in polymyalgia rheumatica

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Publisher
Wiley
Copyright
Copyright © 1982 The Pathological Society of Great Britain and Ireland
ISSN
0022-3417
eISSN
1096-9896
D.O.I.
10.1002/path.1711370303
Publisher site
See Article on Publisher Site

Abstract

Skeletal muscle biopsies of 13 patients with polymyalgia rheumatica (PMR) were examined systematically with the electron microscope. Ultrastructural changes in the PMR specimens have been classified according to 14 criteria including nucleus, myofilaments, mitochondria, T‐system, as well as glycogen deposition, lipid, lipofuscin, and myelin figures. The described muscle changes are of both regressive and progressive character and non‐specific in themselves. The systematic recording of these criteria shows an extraordinaryly high incidence in PMR. This constellation of characteristics gives the ultrastructural picture of the skeletal musculature in PMR a definite profile. Similarities with the changes in other muscular diseases suggest that in PMR also neurogenous mechanisms may play a pathogenetic role.

Journal

The Journal of PathologyWiley

Published: Jul 1, 1982

References

  • Unusual electromyographic findings in a patient with polymyalgia rheumatica
    Gross, Gross; Borkin, Borkin; Rupp, Rupp

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