Ulex europeus I—peroxidase as a marker of vascular endothelium: Its application in routine histopathology

Ulex europeus I—peroxidase as a marker of vascular endothelium: Its application in routine... Peroxidase‐labelled Ulex europeus I lectin has been applied to a series of routinely fixed and processed vascular lesions to assess its value in the identification of endothelium. A group of breast carcinomas previously examined for binding of the lectin to the tumour have been re‐assessed for evaluation of the use of Ulex europeus I in the determination of vascular invasion. There was consistent binding to normal vascular endothelium but this could be variable, there being stronger reactivity in small vessels of some tissues. All benign lesions stained showed clear definition of vascular channels but angiosarcomas were much less consistent in their staining reaction and the peroxidase‐labelled lectin was considered to be a less satisfactory marker. Lymphatic endothelium was always negative; this proved to be a useful feature in differentiating between blood vessel and lymphatic invasion by breast carcinoma. Ulex europeus I‐peroxidase could certainly have a role in routine histopathology in this area. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Pathology Wiley

Ulex europeus I—peroxidase as a marker of vascular endothelium: Its application in routine histopathology

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Publisher
Wiley
Copyright
Copyright © 1985 John Wiley & Sons, Ltd.
ISSN
0022-3417
eISSN
1096-9896
D.O.I.
10.1002/path.1711460207
Publisher site
See Article on Publisher Site

Abstract

Peroxidase‐labelled Ulex europeus I lectin has been applied to a series of routinely fixed and processed vascular lesions to assess its value in the identification of endothelium. A group of breast carcinomas previously examined for binding of the lectin to the tumour have been re‐assessed for evaluation of the use of Ulex europeus I in the determination of vascular invasion. There was consistent binding to normal vascular endothelium but this could be variable, there being stronger reactivity in small vessels of some tissues. All benign lesions stained showed clear definition of vascular channels but angiosarcomas were much less consistent in their staining reaction and the peroxidase‐labelled lectin was considered to be a less satisfactory marker. Lymphatic endothelium was always negative; this proved to be a useful feature in differentiating between blood vessel and lymphatic invasion by breast carcinoma. Ulex europeus I‐peroxidase could certainly have a role in routine histopathology in this area.

Journal

The Journal of PathologyWiley

Published: Jun 1, 1985

References

  • Blood vessel invasion and axillary lymph node involvement as prognostic indicators for human breast cancer
    Weigend, Weigend; Isenberg, Isenberg; Russo, Russo

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