The 2013 tuberculosis (TB) review series ‘Tuberculosis: Current state of knowledge’ highlighted important gaps in our existing knowledge on the complex interactions between the pathogen and the host. We also detailed major limitations in current control strategies. Since then, there have been major developments in new diagnostic tools and drugs/regimens for TB and latent TB infection (LTBI), some of which have modified clinical practice in both high‐ and low‐burden countries. In 2014, the World Health Assembly approved the ‘End TB Strategy’, which set ambitious targets to achieve a 95% reduction in TB death and 90% reduction in TB incidence rate by 2035. To consolidate developments and to meet the upcoming challenges, we have invited a panel of international experts to critically re‐examine the relevant issues in a new series of themed reviews focused on TB.Despite over two decades of effort to find and treat infectious sources, there were still an estimated 10.4 million incident TB cases with 1.7 million deaths in 2016. The annual decline of TB incidence remained at around 2%, not much higher than the annual decline of TB mortality of 1.71% in the United Kingdom in the pre‐chemotherapeutic era. Resistance has also emerged to most of
Respirology – Wiley
Published: Jan 1, 2018
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