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We thank Drs. Scialli and Gibb for their interest in our work (Yauck JS, Malloy ME, Blair K, Simpson PM, McCarver DG. Proximity of Residence to Trichloroethylene‐Emitting Sites and Increased Risk of Offspring Congenital Heart Defects among Older Women. Birth Defects Research (Part A) 2004;70:808–814) and for the opportunity to respond to their comments. Our overall conclusion matches that of Drs. Scialli and Gibb, which is that additional study of the risk of congenital heart defects (CHDs) from trichloroethylene (TCE) is warranted. We believe the language of the article's conclusion, “that the observation significantly adds to the overall body of literature that suggests (emphasis added) TCE is a cardiac teratogen,” was appropriately selected and that it is consistent with this overall conclusion. Notably, we did not state that the specific distance used in our study constitutes a risk factor. As we previously noted, and as Drs. Scialli and Gibb reiterated, several methodologic limitations, including the use of a surrogate exposure variable, merit consideration. The correspondents are concerned that exposure may not have occurred to mothers during their pregnancies or even occurred at all. While there is always some uncertainty when surrogate variables are used, Drs. Scialli and Gibb
Birth Defects Research Part A – Wiley
Published: Apr 1, 2005
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