Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Trichloroethylene and parkinsonism: a human and experimental observation

Trichloroethylene and parkinsonism: a human and experimental observation This report describes the case of a 47‐year‐old woman who developed Parkinson's disease after seven years of professional exposure to trichloroethylene. In the light of this clinical report, mice were intoxicated with trichloroethylene and tyrosine hydroxylase immunoreactivity was used to measure neuronal death in the substantia nigra pars compacta. Treated mice presented significant dopaminergic neuronal death in comparison with control mice (50%). The environmental trichlorethylene pollution, as well as other unspecific neurotoxic solvents, could potentially contribute to the genesis of some cases of Parkinson's disease. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Neurology Wiley

Trichloroethylene and parkinsonism: a human and experimental observation

Loading next page...
 
/lp/wiley/trichloroethylene-and-parkinsonism-a-human-and-experimental-2W5mxSMwqi

References (27)

Publisher
Wiley
Copyright
Copyright © 1999 Wiley Subscription Services, Inc., A Wiley Company
ISSN
1351-5101
eISSN
1468-1331
DOI
10.1046/j.1468-1331.1999.650609.x
Publisher site
See Article on Publisher Site

Abstract

This report describes the case of a 47‐year‐old woman who developed Parkinson's disease after seven years of professional exposure to trichloroethylene. In the light of this clinical report, mice were intoxicated with trichloroethylene and tyrosine hydroxylase immunoreactivity was used to measure neuronal death in the substantia nigra pars compacta. Treated mice presented significant dopaminergic neuronal death in comparison with control mice (50%). The environmental trichlorethylene pollution, as well as other unspecific neurotoxic solvents, could potentially contribute to the genesis of some cases of Parkinson's disease.

Journal

European Journal of NeurologyWiley

Published: Sep 1, 1999

There are no references for this article.