Treatment of raynaud's phenomenon with ketanserin, a selective antagonist of the serotonin 2 (5‐HT 2 ) receptor

Treatment of raynaud's phenomenon with ketanserin, a selective antagonist of the serotonin 2... Ketanserin, a selective antagonist of the 5‐HT2 receptor, was evaluated in a 4‐week open pilot trial of 30 patients with Raynaud's phenomenon. Moderate or marked relief was reported in 15 of 18 (83%) patients with systemic sclerosis, whereas only 4 of 12 (33%) patients with Raynaud's phenomenon of other etiology received such benefit (P < 0.01). These subjective ratings were supported by the results of serial digital strain gauge plethysmography during controlled cold challenge. Additional clinical findings suggested that ketanserin therapy facilitated the healing of ischemic digital ulcerations and reduced hand edema in patients with systemic sclerosis. These findings lend support to the hypothesis that serotonin is an important element in the pathogenesis of systemic sclerosis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Arthritis & Rheumatology Wiley

Treatment of raynaud's phenomenon with ketanserin, a selective antagonist of the serotonin 2 (5‐HT 2 ) receptor

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Publisher
Wiley
Copyright
Copyright © 1984 American College of Rheumatology
ISSN
0004-3591
eISSN
1529-0131
DOI
10.1002/art.1780270204
Publisher site
See Article on Publisher Site

Abstract

Ketanserin, a selective antagonist of the 5‐HT2 receptor, was evaluated in a 4‐week open pilot trial of 30 patients with Raynaud's phenomenon. Moderate or marked relief was reported in 15 of 18 (83%) patients with systemic sclerosis, whereas only 4 of 12 (33%) patients with Raynaud's phenomenon of other etiology received such benefit (P < 0.01). These subjective ratings were supported by the results of serial digital strain gauge plethysmography during controlled cold challenge. Additional clinical findings suggested that ketanserin therapy facilitated the healing of ischemic digital ulcerations and reduced hand edema in patients with systemic sclerosis. These findings lend support to the hypothesis that serotonin is an important element in the pathogenesis of systemic sclerosis.

Journal

Arthritis & RheumatologyWiley

Published: Feb 1, 1984

References

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  • Preliminary criteria for the classification of systemic sclerosis (scleroderma)
    Masi, Masi; Rodnan, Rodnan; Medsger, Medsger; Altman, Altman; D'Angelo, D'Angelo; Fries, Fries; LeRoy, LeRoy; Kirsner, Kirsner; Mackenzie, Mackenzie; McShane, McShane; Myers, Myers; Sharp, Sharp
  • Abnormalities of pulmonary vascular dynamics and inflammation in early progressive systemic sclerosis
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  • 5‐hydroxytryptamine and tryptamine pathways in scleroderma
    Stachow, Stachow; Jablonska, Jablonska; Skiendzielewska, Skiendzielewska

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