Treatment and outcomes of melanoma in Asia: Results from the National Cancer Centre Singapore

Treatment and outcomes of melanoma in Asia: Results from the National Cancer Centre Singapore 1INTRODUCTIONMelanoma is an aggressive malignancy associated with significant clinical, biological and epidemiological heterogeneity. It affects Caucasian populations more commonly than peoples with pigmented skin, including Asians. Data from the National Cancer Institute Surveillance, Epidemiology and End Results Program (SEER) revealed an age‐adjusted incidence of 21.9 persons per 100 000 population per year in non‐Hispanic “whites,” as opposed to < 5 per 100 000 for all other ethnicities; the incidence in Asians was 1.5 per 100 000. In spite of these ethnogeographic disparities in incidence, advanced melanoma has a universally poor prognosis, with 5‐year survival in metastatic disease at 10–15%.The modern taxonomy of melanocytic neoplasia derives from a seminal publication by Curtin and colleagues who established four clinically defined categories that are genetically distinct. The first two categories are cutaneous melanomas (CMs) developing in sun‐exposed skin that are distinguished by the extent of cumulative sun damage (CSD), defined by the degree of associated solar elastosis. Melanomas with evidence of extensive damage are termed CSD melanomas, while those with evidence of minimal damage are called non‐CSD melanomas. The other two categories arise in relatively sun‐protected anatomic sites – acral melanomas (AMs) refer to disease affecting the nail‐beds and glabrous skin of palms and soles, while mucosal http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Asia-Pacific Journal of Clinical Oncology Wiley

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2018 John Wiley & Sons Australia, Ltd
ISSN
1743-7555
eISSN
1743-7563
D.O.I.
10.1111/ajco.12802
Publisher site
See Article on Publisher Site

Abstract

1INTRODUCTIONMelanoma is an aggressive malignancy associated with significant clinical, biological and epidemiological heterogeneity. It affects Caucasian populations more commonly than peoples with pigmented skin, including Asians. Data from the National Cancer Institute Surveillance, Epidemiology and End Results Program (SEER) revealed an age‐adjusted incidence of 21.9 persons per 100 000 population per year in non‐Hispanic “whites,” as opposed to < 5 per 100 000 for all other ethnicities; the incidence in Asians was 1.5 per 100 000. In spite of these ethnogeographic disparities in incidence, advanced melanoma has a universally poor prognosis, with 5‐year survival in metastatic disease at 10–15%.The modern taxonomy of melanocytic neoplasia derives from a seminal publication by Curtin and colleagues who established four clinically defined categories that are genetically distinct. The first two categories are cutaneous melanomas (CMs) developing in sun‐exposed skin that are distinguished by the extent of cumulative sun damage (CSD), defined by the degree of associated solar elastosis. Melanomas with evidence of extensive damage are termed CSD melanomas, while those with evidence of minimal damage are called non‐CSD melanomas. The other two categories arise in relatively sun‐protected anatomic sites – acral melanomas (AMs) refer to disease affecting the nail‐beds and glabrous skin of palms and soles, while mucosal

Journal

Asia-Pacific Journal of Clinical OncologyWiley

Published: Jan 1, 2018

Keywords: ; ; ; ; ;

References

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