Transfusion‐transmitted human parvovirus B19 infection in a thalassemic patient

Transfusion‐transmitted human parvovirus B19 infection in a thalassemic patient BACKGROUND: Human parvovirus (HPV) B19 infection has been shown to be transmissible by clotting factor concentrates, most often resulting in asymptomatic seroconversion. So far, no case of B19 transmission due to single‐donor transfusion has been documented. CASE REPORT: A case of transfusion‐transmitted HPV B19 infection in a 22‐year‐old female thalassemia major patient is described. She presented with an aplastic crisis; this was followed 1 week later by transitory heart failure and acute tricuspid incompetence. The echocardiogram revealed a grade III tricuspid regurgitation and a floating vegetation on the atrial face of the tricuspid lateral leaflet. The tricuspid regurgitation and vegetation spontaneously disappeared within 15 days. Blood cultures for bacteria were repeatedly negative. IgM anti‐HPV B19 seroconversion was documented in the acute phase. B19 DNA was detected by polymerase chain reaction and remained detectable up to 4 months after diagnosis. High‐ titer IgM anti‐HPV and B19 DNA were also found in serum samples collected at the time of donation from one of the donors of the blood transfused before the onset of clinical symptoms. CONCLUSION: This case documents the transmission of HPV B19 by the transfusion of 1 red cell unit and the occurrence of possible transient cardiac involvement in this infectious complication. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Transfusion Wiley

Transfusion‐transmitted human parvovirus B19 infection in a thalassemic patient

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Publisher
Wiley
Copyright
1995 AABB
ISSN
0041-1132
eISSN
1537-2995
DOI
10.1046/j.1537-2995.1995.35996029163.x
Publisher site
See Article on Publisher Site

Abstract

BACKGROUND: Human parvovirus (HPV) B19 infection has been shown to be transmissible by clotting factor concentrates, most often resulting in asymptomatic seroconversion. So far, no case of B19 transmission due to single‐donor transfusion has been documented. CASE REPORT: A case of transfusion‐transmitted HPV B19 infection in a 22‐year‐old female thalassemia major patient is described. She presented with an aplastic crisis; this was followed 1 week later by transitory heart failure and acute tricuspid incompetence. The echocardiogram revealed a grade III tricuspid regurgitation and a floating vegetation on the atrial face of the tricuspid lateral leaflet. The tricuspid regurgitation and vegetation spontaneously disappeared within 15 days. Blood cultures for bacteria were repeatedly negative. IgM anti‐HPV B19 seroconversion was documented in the acute phase. B19 DNA was detected by polymerase chain reaction and remained detectable up to 4 months after diagnosis. High‐ titer IgM anti‐HPV and B19 DNA were also found in serum samples collected at the time of donation from one of the donors of the blood transfused before the onset of clinical symptoms. CONCLUSION: This case documents the transmission of HPV B19 by the transfusion of 1 red cell unit and the occurrence of possible transient cardiac involvement in this infectious complication.

Journal

TransfusionWiley

Published: Sep 1, 1995

References

  • Rheumatologic manifestations of human parvovirus B19 infection in adults
    Naides, Naides; Scharosch, Scharosch; Foto, Foto; Howard, Howard
  • Human parvoviruses: implications for transfusion medicine
    Luban, Luban
  • Should measures be taken to reduce the risk of human parvovirus (B19) infection by transfusion of blood components and clotting factor concentrates?
    Mosley, Mosley
  • Human parvovirus infection in haemophiliacs first infused with treated clotting factor concentrates
    Corsi, Corsi; Azzi, Azzi; Morfini, Morfini; Fanci, Fanci; Ferrini, Ferrini
  • Transmission of human parvovirus B19 by coagulation factor concentrates
    Williams, Williams; Cohen, Cohen; Beddall, Beddall; Pasi, Pasi; Mortimer, Mortimer; Hill, Hill

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