Transferrin and its receptor: Their roles in cell function

Transferrin and its receptor: Their roles in cell function Transferrin, its receptor and the entry of iron into the cell have sprung into prominence because of recent evidence that proliferation of various cell types involves regulation of this sequence of events, as evidenced especially by changes in receptor number. A third component functionally linked to transferrin and its receptor is the intracellular iron‐storage protein, ferritin, which ensures against toxic levels of free ferrous iron, which might otherwise cause peroxidative damage to cell membranes and other cell structures (1). In this article, we shall focus on interactions between these three proteins of iron exchange, their roles in homeostasis and especially their role in relation to the liver which is a major organ of iron storage. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Hepatology Wiley

Transferrin and its receptor: Their roles in cell function

Hepatology, Volume 5 (5) – Sep 1, 1985

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Publisher
Wiley
Copyright
Copyright © 1985 American Association for the Study of Liver Diseases
ISSN
0270-9139
eISSN
1527-3350
DOI
10.1002/hep.1840050528
Publisher site
See Article on Publisher Site

Abstract

Transferrin, its receptor and the entry of iron into the cell have sprung into prominence because of recent evidence that proliferation of various cell types involves regulation of this sequence of events, as evidenced especially by changes in receptor number. A third component functionally linked to transferrin and its receptor is the intracellular iron‐storage protein, ferritin, which ensures against toxic levels of free ferrous iron, which might otherwise cause peroxidative damage to cell membranes and other cell structures (1). In this article, we shall focus on interactions between these three proteins of iron exchange, their roles in homeostasis and especially their role in relation to the liver which is a major organ of iron storage.

Journal

HepatologyWiley

Published: Sep 1, 1985

References

  • In vitro and in vivo studies of iron delivery by human monoferric transferrins
    Van der Heul, Van der Heul; Kroos, Kroos; van Noort, van Noort
  • Endocytosis and the recycling of plasma membrane
    Steinman, Steinman; Mellman, Mellman; Muller, Muller
  • Rapid endocytosis of the transferrin receptor in the absence of bound transferrin
    Watts, Watts
  • Regulation of K562 cell transferrin receptors by exogenous iron
    Rudolph, Rudolph; Ohlsson‐Wilhelm, Ohlsson‐Wilhelm; Leary, Leary
  • Transferrin receptor expression during exponential and plateau phase of growth of human tumour cells in culture
    Musgrove, Musgrove; Rugg, Rugg; Taylor, Taylor
  • Uptake and release of transferrin and iron by mitogen‐stimulated human lymphocytes
    Bomford, Bomford; Young, Young; Nouri‐Aria, Nouri‐Aria
  • A lipophilic iron chelator can replace transferrin as a stimulator of cell proliferation and differentiation
    Landschulz, Landschulz; Thesleff, Thesleff; Ekblom, Ekblom
  • The amount of ferritin and hemosiderin in the livers of patients with iron‐loading diseases
    Zuyderhoudt, Zuyderhoudt; Sindram, Sindram; Marx, Marx
  • Transferrin receptors and the uptake and release of iron by isolated hepatocytes
    Young, Young; Aisen, Aisen
  • Ferritin: structure, biosynthesis and role in iron metabolism
    Munro, Munro; Linder, Linder
  • The role of iron in the regulation of hepatic transferrin synthesis
    Morton, Morton; Tavill, Tavill
  • The control of hepatic iron uptake: correlation with transferrin synthesis
    Morton, Morton; Tavill, Tavill

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