Transepidermal water loss and absorption of hydrocortisone in widespread dermatitis

Transepidermal water loss and absorption of hydrocortisone in widespread dermatitis Summary Percutaneous absorption of hydrocortisone was measured in tbree children and six adults with widespread dermatitis, after the application of 1% bydrocortisone cream. Before appiication of the cream, the transepidermal water loss (TEWL) was measured on six skin areas. A highly significant correlation was found between the post‐application rise in plasma cortisol level and the mean transepidermal water loss. Thus, measurement of TEWL affords a simple, non‐invasive method for assessing the systemic effect of hydrocortisone applied to widespread dermatitis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png British Journal of Dermatology Wiley

Transepidermal water loss and absorption of hydrocortisone in widespread dermatitis

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Publisher
Wiley
Copyright
Copyright © 1993 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0007-0963
eISSN
1365-2133
DOI
10.1111/j.1365-2133.1993.tb00258.x
Publisher site
See Article on Publisher Site

Abstract

Summary Percutaneous absorption of hydrocortisone was measured in tbree children and six adults with widespread dermatitis, after the application of 1% bydrocortisone cream. Before appiication of the cream, the transepidermal water loss (TEWL) was measured on six skin areas. A highly significant correlation was found between the post‐application rise in plasma cortisol level and the mean transepidermal water loss. Thus, measurement of TEWL affords a simple, non‐invasive method for assessing the systemic effect of hydrocortisone applied to widespread dermatitis.

Journal

British Journal of DermatologyWiley

Published: Jun 1, 1993

References

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