Transducing Hedgehog: the story so far

Transducing Hedgehog: the story so far The secreted proteins of the Hedgehog family have been implicated in many different processes in vertebrate development including cartilage differentiation, myotome and sclerotome specification, hair follicle development, limb morphogenesis and the specification of different neuronal cell types. In addition, the aberrant activation of the Hedgehog pathway has been identified as the likely cause of a number of tumours in humans including basal cell carcinomas (BCCs) and primitive neurectodermal tumours (PNETs). Elucidating the mechanisms by which Hedgehog signals are transduced will thus have widespread implications for our understanding of both normal development and disease. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The EMBO Journal Wiley

Transducing Hedgehog: the story so far

The EMBO Journal, Volume 17 (13) – Jan 1, 1998

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Publisher
Wiley
Copyright
Copyright © 2013 Wiley Periodicals, Inc
ISSN
0261-4189
eISSN
1460-2075
DOI
10.1093/emboj/17.13.3505
Publisher site
See Article on Publisher Site

Abstract

The secreted proteins of the Hedgehog family have been implicated in many different processes in vertebrate development including cartilage differentiation, myotome and sclerotome specification, hair follicle development, limb morphogenesis and the specification of different neuronal cell types. In addition, the aberrant activation of the Hedgehog pathway has been identified as the likely cause of a number of tumours in humans including basal cell carcinomas (BCCs) and primitive neurectodermal tumours (PNETs). Elucidating the mechanisms by which Hedgehog signals are transduced will thus have widespread implications for our understanding of both normal development and disease.

Journal

The EMBO JournalWiley

Published: Jan 1, 1998

Keywords: ; ; ;

References

  • Sonic hedgehog differentially regulates expression of Gli and Gli3 during limb development
    Marigo, V; Johnson, R; Vortkamp, A; Tabin, C
  • Requirements for hedgehog, a segment polarity gene, in patterning larval and adult cuticle of Drosophila
    Mohler, J
  • Segmental polarity in Drosophila melanogaster: genetic dissection of fused in a Suppressor of fused background reveals interaction with costal‐2
    Préat, T; Thérond, P; Limbourg‐Bouchon, B; Pham, A; Tricoire, H; Busson, D; Lamour‐Isnard, D
  • Mutations that alter the timing and pattern of cubitus interruptus gene expression in Drosophila melanogaster
    Slusarski, DC; Motzny, CK; Holmgren, R

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