Transcription factors and head formation in vertebrates

Transcription factors and head formation in vertebrates Evidence from Drosophila and also vertebrates predicts that two different sets of instructions may determine the development of the rostral and caudal parts of the body. This implies different cellular and inductive processes during gastrulation, whose genetic requirements remain to be understood. To date, four genes encoding transcription factors expressed in the presumptive vertebrate head during gastrulation have been studied at the functional level: Lim‐1, Otx‐2, HNF‐3β and goosecoid. We discuss here the potential functions of these genes in the formation of rostral head as compared to posterior head and trunk, and in the light of recent fate map and expression analyses in mouse, chick, Xenopus and zebrafish. These data indicate that Lim‐1, Otx‐2 and HNF‐3β may be involved in the same genetic pathway controlling the formation of the prechordal mesendoderm, which is subsequently required for rostral head development. goosecoid may act in a parallel pathway, possibly in conjunction with other, yet unidentified, factors. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png BioEssays Wiley

Transcription factors and head formation in vertebrates

BioEssays, Volume 19 (2) – Feb 1, 1997

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Publisher
Wiley
Copyright
Copyright © 1997 Cambridge University Press
ISSN
0265-9247
eISSN
1521-1878
DOI
10.1002/bies.950190207
pmid
9046242
Publisher site
See Article on Publisher Site

Abstract

Evidence from Drosophila and also vertebrates predicts that two different sets of instructions may determine the development of the rostral and caudal parts of the body. This implies different cellular and inductive processes during gastrulation, whose genetic requirements remain to be understood. To date, four genes encoding transcription factors expressed in the presumptive vertebrate head during gastrulation have been studied at the functional level: Lim‐1, Otx‐2, HNF‐3β and goosecoid. We discuss here the potential functions of these genes in the formation of rostral head as compared to posterior head and trunk, and in the light of recent fate map and expression analyses in mouse, chick, Xenopus and zebrafish. These data indicate that Lim‐1, Otx‐2 and HNF‐3β may be involved in the same genetic pathway controlling the formation of the prechordal mesendoderm, which is subsequently required for rostral head development. goosecoid may act in a parallel pathway, possibly in conjunction with other, yet unidentified, factors.

Journal

BioEssaysWiley

Published: Feb 1, 1997

References

  • Common ground plans in early brain development in mice and flies
    Arendt, Arendt; Nübler‐Jung, Nübler‐Jung
  • Determination events in the nervous system of the vertebrate embryo
    Bally‐Cuif, Bally‐Cuif; Wassef, Wassef
  • The cellular basis of the convergence and extension of the Xenopus neural plate
    Keller, Keller; Shih, Shih; Sater, Sater
  • Homeobox genes in vertebrate gastrulation
    Boncinelli, Boncinelli; Mallamaci, Mallamaci
  • Mapping vertebrate embryos
    Tam, Tam; Quilan, Quilan
  • A series of normal stages in the development of the chick embryo
    Hamburger, Hamburger; Hamilton, Hamilton
  • Stages of embryonic development in the zebrafish
    Kimmel, Kimmel; Ballard, Ballard; Kimmel, Kimmel; Ullmann, Ullmann; Schilling, Schilling

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