hecia1 Articles Three Recently Described Animal Virus Models for Human Hepatitis B Virus JESSESUMMERS Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 191 11 This issue of Hepatology contains an article by Popper and his collaborators describing the histopathologic findings associated with a hepatitis virus infection of the eastern woodchuck (Marmota monax). This virus, known as the woodchuck hepatitis virus (WHV), was described several years ago as being the only other identified member of the human hepatitis B virus (HBV) and family (l), is currently under investigation in several laboratories as an animal virus model for HBV. In the past few years, two additional viruses which are phylogenetically related to the human HBV have been discovered in animals. The family of hepatitis-B-like viruses now includes HBV, WHV, ground squirrel hepatitis virus (GSHV) ( 2 ) ,and duck hepatitis B virus (DHBV) (3).The newly discovered animal viruses provide an opportunity to study in the laboratory the replication of HBV-like viruses and their role in the oncogenic process. For this reason, a brief review of the properties of these potentially important models is appropriate. It has become clear during the 10 yr since the description of so-called âDaneâ
Hepatology – Wiley
Published: Mar 1, 1981
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