(AACC) Synthesis of Enhanced Emission Solvatochromic
How would you describe to the layperson the most
significant result of this study?
It is like cooking in the kitchen with astyle to prepare aone-pot
pasta, the difference being that in our case, we produce colorful
What was the inspiration for this cover design?
The idea to show glowing pyrazine-based chromophores in the
dark is relatively obvious, if you work with such dyes. But also,
3-ethynylchinoxalines can shine in solution and in the solid state
on alarge stage with aspotlight. For this reason, we have cut
NMR tubes and prepared stencils to create the 3-ethynylchinox-
aline structure. Through the diversity-oriented one-pot approach, a
wide variety is accessible, which also affected the emission colors.
What prompted you to investigate this topic/problem?
One of our research lines focuses on multicomponent reactions
and one-pot procedures. Our group has tackled related projects
before, which focused on the GACC sequence (glyoxylation-alkyny-
lation-cyclocondensation). Although it has been successful, it soon
became apparent that there was also alimitation to overcome re-
garding some interesting substituents. Thus, we altered our strat-
egy taking advantage of another synthetic concept, the AACC se-
quence (activation-alkynylation-cyclocondensation), which was also
developed in our group. From the first projects, we simultaneously
increased our knowledge about the photophysical properties of
the substance class of 3-ethynylquinoxalines. Therefore, we could
enhance the desired properties of the second generation systemat-
Invited for the cover of this issue is the group of Thomas J. J. Müller at the Heinrich-Heine-UniversitätDüsseldorf. The image
depicts some of the fluorescentcompounds synthesized in this study.Read the full text of the articleat10.1002/
Franziska K. Merkt Simon P. Hçwedes Charlotte F. Gers-
IrinaGruber Christoph Janiak ThomasJ.J.Müller
Chem. Eur.J.2018, 24,8021 2018 Wiley-VCH Verlag GmbH &Co. KGaA, Weinheim8021