Thermo and pH dual‐responsive nanoparticles encapsulating an anti‐cancer drug (paclitaxel) were assembled from a diblock copolymer comprised of a hydrophilic poly(N‐isopropylacrylamide‐co‐acrylic acid) block and a hydrophobic polycaprolactone block. These nanoparticles aggregated at body temperature under a slightly acidic pH of 6.9 (see figure), and a faster drug release was found to be associated with higher temperature and lower pH, both of which are advantageous for tumor‐targeted anti‐caner drug delivery.
Advanced Materials – Wiley
Published: Jan 5, 2007
Keywords: ; ;
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