1INTRODUCTIONIn New Zealand, the presence of the biomarker human epidermal growth factor receptor 2 (HER2) in women with breast cancer has been commonly ascertained since 1998, and routinely since 2006. It has been found to be present in approximately 15–20% of breast cancers, presenting more commonly in breast cancers of younger women. It is known that women who have HER2 positive (+ve) breast cancer have a poorer prognosis compared to women with HER2 negative (–ve) disease.Trastuzumab (Herceptin) is a targeted therapy for patients with HER2+ve breast cancer. Randomized clinical trials have shown that trastuzumab reduced breast cancer recurrence and mortality in women with early‐stage HER2+ve breast cancer after surgery. A study combining data from the National Surgical Adjuvant Breast and Bowel Project (NSABP) B‐31 and North Central Cancer Treatment Group (NCCTG) N9831 clinical trials with a median follow‐up time of 8 years demonstrated a hazard ratio of 0.63 (95% CI: 0.54–0.73) in breast cancer‐specific mortality and a hazard ratio of 0.60 (95% CI: 0.53–0.68) in all‐cause mortality after adding 12 months trastuzumab to chemotherapy for HER2+ve stage I–III breast cancer.Trastuzumab was first licensed by the US FDA (Federal Drug Regulatory Authority) in 1998 for metastatic HER2+ve breast cancer and
Asia-Pacific Journal of Clinical Oncology – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ;
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