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The Structure and Function of Catalytic Domains Within Inositol Polyphosphate 5‐Phosphatases

The Structure and Function of Catalytic Domains Within Inositol Polyphosphate 5‐Phosphatases Phosphoinositide signaling pathways regulate many essential cellular functions including proliferation, differentiation and survival, cytoskeletal organization, and vesicular trafficking. The inositol polyphosphate 5‐phosphatases regulate the cellular levels of several bioactive phosphoinositide species. This review describes the structure and function of the 5‐phosphatase and Sac1 catalytic domains of these enzymes. The crystal structure of the 5‐phosphatase domain has been solved and shares homology with members of the AP endonuclease family. The phosphoinositide polyphosphatase activity of the Sac1 domain, found in some inositol polyphosphate 5‐phosphatases, is defined by a motif, CX 5 R(T/S), also found in both protein and lipid phosphatases. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png IUBMB Life Wiley

The Structure and Function of Catalytic Domains Within Inositol Polyphosphate 5‐Phosphatases

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References (80)

Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2002 International Union of Biochemistry and Molecular Biology
ISSN
1521-6543
eISSN
1521-6551
DOI
10.1080/15216540210814
pmid
12018403
Publisher site
See Article on Publisher Site

Abstract

Phosphoinositide signaling pathways regulate many essential cellular functions including proliferation, differentiation and survival, cytoskeletal organization, and vesicular trafficking. The inositol polyphosphate 5‐phosphatases regulate the cellular levels of several bioactive phosphoinositide species. This review describes the structure and function of the 5‐phosphatase and Sac1 catalytic domains of these enzymes. The crystal structure of the 5‐phosphatase domain has been solved and shares homology with members of the AP endonuclease family. The phosphoinositide polyphosphatase activity of the Sac1 domain, found in some inositol polyphosphate 5‐phosphatases, is defined by a motif, CX 5 R(T/S), also found in both protein and lipid phosphatases.

Journal

IUBMB LifeWiley

Published: Jan 1, 2002

Keywords: Ap Endonucleases; Inositol Polyphosphate 5‐phosphatases; Phosphoinositides; Sac1; Second Messengers; Trafficking

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