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R. Mehra, S. Varambally, L. Ding, R. Shen, M. Sabel, D. Ghosh, A. Chinnaiyan, C. Kleer (2005)
Identification of GATA3 as a breast cancer prognostic marker by global gene expression meta-analysis.Cancer research, 65 24
T. Sørlie, C. Perou, R. Tibshirani, T. Aas, S. Geisler, H. Johnsen, T. Hastie, M. Eisen, M. Rijn, S. Jeffrey, T. Thorsen, H. Quist, J. Matese, P. Brown, D. Botstein, P. Lønning, A. Børresen-Dale (2001)
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implicationsProceedings of the National Academy of Sciences of the United States of America, 98
P. Stephens, P. Tarpey, H. Davies, P. Loo, C. Greenman, D. Wedge, S. Nik-Zainal, Sancha Martin, I. Varela, G. Bignell, L. Yates, E. Papaemmanuil, D. Beare, A. Butler, Angela Cheverton, John Gamble, Jonathan Hinton, Mingming Jia, Alagurevathi Jayakumar, David Jones, Calli Latimer, K. Lau, Stuart Mclaren, D. Mcbride, A. Menzies, L. Mudie, K. Raine, R. Rad, M. Chapman, J. Teague, D. Easton, A. Langerød, Rolf Ottestad, R. Kåresen, E. Schlichting, B. Naume, Torill Sauer, L. Ottestad, M. Lee, Chen-Yang Shen, Benita Tee, Bernice Huimin, A. Broeks, A. Vargas, G. Turashvili, J. Martens, Aquila Fatima, P. Miron, S. Chin, G. Thomas, S. Boyault, O. Mariani, S. Lakhani, M. Vijver, L. Veer, J. Foekens, C. Desmedt, C. Sotiriou, A. Tutt, C. Caldas, J. Reis-Filho, S. Aparicio, A. Salomon, A. Børresen-Dale, A. Richardson, P. Campbell, P. Futreal, M. Stratton (2012)
The landscape of cancer genes and mutational processes in breast cancerNature, 486
L. Shan, Xin Li, Ling Liu, Xiang Ding, Qian Wang, Y. Zheng, Y. Duan, C. Xuan, Yuejiao Wang, Fan Yang, Yongfeng Shang, Lei Shi (2014)
GATA3 cooperates with PARP1 to regulate CCND1 transcription through modulating histone H1 incorporationOncogene, 33
Copyright © American Society for Investigative Pathology Short Communication Expression of Cytokeratins 17 and 5 Identifies a Group of Breast Carcinomas with Poor Clinical Outcome
E. Azambuja, F. Cardoso, G. Castro, M. Colozza, M. Mano, V. Durbecq, C. Sotiriou, D. Larsimont, M. Piccart-Gebhart, M. Paesmans (2007)
Ki-67 as prognostic marker in early breast cancer: a meta-analysis of published studies involving 12 155 patientsBritish Journal of Cancer, 96
M. Dolled-Filhart, L. Rydén, M. Cregger, K. Jirström, M. Harigopal, R. Camp, D. Rimm (2006)
Classification of Breast Cancer Using Genetic Algorithms and Tissue MicroarraysClinical Cancer Research, 12
H. Esch, P. Groenen, M. Nesbit, S. Schuffenhauer, P. Lichtner, G. Vanderlinden, B. Harding, R. Beetz, Rudolf Bilous, I. Holdaway, Nicholas Shaw, J. Fryns, W. Ven, R. Thakker, K. Devriendt (2000)
GATA3 haplo-insufficiency causes human HDR syndromeNature, 406
N. Tominaga, Y. Naoi, K. Shimazu, T. Nakayama, N. Maruyama, A. Shimomura, Sj Kim, Y. Tamaki, S. Noguchi (2012)
Clinicopathological analysis of GATA3-positive breast cancers with special reference to response to neoadjuvant chemotherapy.Annals of oncology : official journal of the European Society for Medical Oncology, 23 12
A. Fox, C. Liew, M. Holmes, K. Kowalski, J. Mackay, M. Crossley (1999)
Transcriptional cofactors of the FOG family interact with GATA proteins by means of multiple zinc fingersThe EMBO Journal, 18
B. Antonsson, F. Conti, AnnaMaria Ciavatta, S. Montessuit, Shareta Lewis, I. Martinou, L. Bernasconi, Alain Bernard, J. Mermod, G. Mazzei, K. Maundrell, F. Gambale, R. Sadoul, J. Martinou (1997)
Inhibition of Bax channel-forming activity by Bcl-2.Science, 277 5324
Helit Cohen, Rotem Ben-Hamo, Moriah Gidoni, I. Yitzhaki, Renana Kozol, A. Zilberberg, S. Efroni (2014)
Shift in GATA3 functions, and GATA3 mutations, control progression and clinical presentation in breast cancerBreast Cancer Research : BCR, 16
E. Janda, K. Lehmann, I. Killisch, M. Jechlinger, M. Herzig, J. Downward, H. Beug, S. Grünert (2002)
Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways.The Journal of cell biology, 156 2
J. Stingl (2009)
Detection and analysis of mammary gland stem cellsThe Journal of Pathology, 217
Alana Philips, J. Kwok, B. Chong (2007)
Analysis of the Signals and Mechanisms Mediating Nuclear Trafficking of GATA-4Journal of Biological Chemistry, 282
Aditi Kanhere, Arnulf Hertweck, Urvashi Bhatia, M. Gökmen, E. Perucha, I. Jackson, Graham Lord, Richard Jenner (2012)
T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elementsNature Communications, 3
V. Theodorou, R. Stark, S. Menon, J. Carroll (2013)
GATA3 acts upstream of FOXA1 in mediating ESR1 binding by shaping enhancer accessibilityGenome Research, 23
Dong-hong Zhang, L. Cohn, P. Ray, K. Bottomly, A. Ray (1997)
Transcription Factor GATA-3 Is Differentially Expressed in Murine Th1 and Th2 Cells and Controls Th2-specific Expression of the Interleukin-5 Gene*The Journal of Biological Chemistry, 272
K. Rehorn, Heidi Thelen, A. Michelson, R. Reuter (1996)
A molecular aspect of hematopoiesis and endoderm development common to vertebrates and Drosophila.Development, 122 12
C. Kaufman, P. Zhou, H. Pasolli, Michael Rendl, D. Bolotin, K. Lim, X. Dai, M. Alegre, E. Fuchs (2003)
GATA-3: an unexpected regulator of cell lineage determination in skin.Genes & development, 17 17
Alayne Brunner, Jun Li, Xiangqian Guo, Robert Sweeney, S. Varma, Shirley Zhu, Rui Li, R. Tibshirani, R. West (2014)
A shared transcriptional program in early breast neoplasias despite genetic and clinical distinctionsGenome Biology, 15
H. Kouros-Mehr, S. Bechis, E. Slorach, L. Littlepage, M. Egeblad, A. Ewald, S. Pai, I. Ho, Z. Werb (2008)
GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model.Cancer cell, 13 2
C. Frelin, Robert Herrington, S. Janmohamed, M. Barbara, Gary Tran, C. Paige, P. Benveniste, J. Zúñiga-Pflücker, A. Souabni, M. Busslinger, N. Iscove (2013)
GATA-3 REGULATES THE SELF-RENEWAL OF LONG-TERM HEMATOPOIETIC STEM CELLSNature immunology, 14
Wei Yan, Q. Cao, R. Arenas, Brooke Bentley, R. Shao (2010)
GATA3 Inhibits Breast Cancer Metastasis through the Reversal of Epithelial-Mesenchymal Transition*The Journal of Biological Chemistry, 285
Yang (1994)
Human GATA-3 trans-activation, DNA-binding, and nuclear localization activities are organized into distinct structural domainsMol Cell Biol, 14
Kasi McCune, P. Bhat-Nakshatri, M. Thorat, K. Nephew, S. Badve, H. Nakshatri (2010)
Prognosis of hormone-dependent breast cancers: implications of the presence of dysfunctional transcriptional networks activated by insulin via the immune transcription factor T-bet.Cancer research, 70 2
M. Asselin-Labat, K. Sutherland, H. Barker, Richard Thomas, M. Shackleton, N. Forrest, L. Hartley, L. Robb, F. Grosveld, J. Wees, G. Lindeman, J. Visvader (2007)
Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiationNature Cell Biology, 9
J. Grogan, R. Locksley (2002)
T helper cell differentiation: on again, off again.Current opinion in immunology, 14 3
I. Tindemans, Nicolas Serafini, J. Santo, R. Hendriks (2014)
GATA-3 function in innate and adaptive immunity.Immunity, 41 2
H. Kendrick, J. Regan, Fiona-Ann Magnay, A. Grigoriadis, C. Mitsopoulos, M. Zvelebil, M. Smalley (2008)
Transcriptome analysis of mammary epithelial subpopulations identifies novel determinants of lineage commitment and cell fateBMC Genomics, 9
C. Denkert, S. Loibl, B. Müller, H. Eidtmann, W. Schmitt, W. Eiermann, B. Gerber, H. Tesch, J. Hilfrich, J. Huober, T. Fehm, J. Barinoff, C. Jackisch, J. Prinzler, T. Rüdiger, E. Erbstößer, J. Blohmer, J. Budczies, K. Mehta, G. Minckwitz (2013)
Ki67 levels as predictive and prognostic parameters in pretherapeutic breast cancer core biopsies: a translational investigation in the neoadjuvant GeparTrio trial.Annals of oncology : official journal of the European Society for Medical Oncology, 24 11
Meixia Zhou, W. Ouyang, Q. Gong, S. Katz, J. White, S. Orkin, K. Murphy (2001)
Friend of GATA-1 Represses GATA-3–dependent Activity in CD4+ T CellsThe Journal of Experimental Medicine, 194
Jae-Woong Lee, Hyeng-Soo Kim, S. Kim, Junmo Hwang, Young Kim, G. Lim, Wern-Joo Sohn, S. Yoon, Jae-Young Kim, T. Park, K. Park, Z. Ryoo, Sanggyu Lee (2012)
DACH1 regulates cell cycle progression of myeloid cells through the control of cyclin D, Cdk 4/6 and p21Cip1.Biochemical and biophysical research communications, 420 1
Yuan Zhang, Yaguang Zhang, Wangpeng Gu, Bing Sun (2014)
TH1/TH2 cell differentiation and molecular signals.Advances in experimental medicine and biology, 841
D. Bates, Yongheng Chen, Grace Kim, Liang Guo, Lin Chen (2008)
Crystal structures of multiple GATA zinc fingers bound to DNA reveal new insights into DNA recognition and self-association by GATA.Journal of molecular biology, 381 5
S. Banerji, K. Cibulskis, C. Rangel-Escareño, K. Brown, S. Carter, A. Frederick, M. Lawrence, A. Sivachenko, C. Sougnez, L. Zou, M. Cortés, J. Fernández-López, Shouyong Peng, K. Ardlie, D. Auclair, V. Bautista-Piña, F. Duke, J. Francis, Joonil Jung, A. Maffuz-Aziz, R. Onofrio, Melissa Parkin, Nam Pho, Valeria Quintanar-Jurado, A. Ramos, R. Rebollar-Vega, S. Rodriguez-Cuevas, S. Romero-Cordoba, S. Schumacher, Nicolas Stransky, K. Thompson, L. Uribe-Figueroa, J. Baselga, R. Beroukhim, K. Polyak, D. Sgroi, A. Richardson, G. Jiménez-Sánchez, E. Lander, S. Gabriel, L. Garraway, T. Golub, J. Meléndez-Zajgla, A. Toker, G. Getz, A. Hidalgo-Miranda, M. Meyerson (2012)
Sequence analysis of mutations and translocations across breast cancer subtypesNature, 486
Jerry Usary, V. Llaca, G. Karaca, Shafaq Presswala, M. Karaca, Xiaping He, Anita Langer, R. Kåresen, D. Oh, L. Dressler, R. Strausberg, S. Chanock, rresen-Dale, C. Perou (2004)
Mutation of GATA 3 in human breast tumors
E. Janda, K. Lehmann, I. Killisch, M. Jechlinger, M. Herzig, J. Downward, H. Beug, S. Grünert (2002)
Ras and TGFβ cooperatively regulate epithelial cell plasticity and metastasisThe Journal of Cell Biology, 156
Wei Yan, R. Shao (2006)
Transduction of a Mesenchyme-specific Gene Periostin into 293T Cells Induces Cell Invasive Activity through Epithelial-Mesenchymal Transformation*Journal of Biological Chemistry, 281
Kongming Wu, X. Jiao, Zhaoming Li, S. Katiyar, Mathew Casimiro, Wancai Yang, Qiong Zhang, Nicole Willmarth, I. Chepelev, M. Crosariol, Zhang Wei, Junbo Hu, K. Zhao, R. Pestell (2010)
Cell Fate Determination Factor Dachshund Reprograms Breast Cancer Stem Cell Function*The Journal of Biological Chemistry, 286
H. Kouros-Mehr, E. Slorach, M. Sternlicht, Z. Werb (2006)
GATA-3 Maintains the Differentiation of the Luminal Cell Fate in the Mammary GlandCell, 127
B. Boyer, A. Vallés, J. Thiery (1996)
Model systems of epithelium-mesenchyme transitions.Acta anatomica, 156 3
Renee Hoch, Devon Thompson, Robin Baker, R. Weigel (1999)
GATA‐3 is expressed in association with estrogen receptor in breast cancerInternational Journal of Cancer, 84
K. Gaynor, I. Grigorieva, Michael Allen, C. Esapa, R. Head, P. Gopinath, P. Christie, M. Nesbit, J. Jones, R. Thakker (2013)
GATA3 Mutations Found in Breast Cancers May Be Associated with Aberrant Nuclear Localization, Reduced Transactivation and Cell InvasivenessHormones and Cancer, 4
M. Yamashita, Maki Ukai-Tadenuma, T. Miyamoto, K. Sugaya, H. Hosokawa, A. Hasegawa, M. Kimura, M. Taniguchi, J. DeGregori, T. Nakayama (2004)
Essential Role of GATA3 for the Maintenance of Type 2 Helper T (Th2) Cytokine Production and Chromatin Remodeling at the Th2 Cytokine Gene Loci*Journal of Biological Chemistry, 279
P. Pandolfi, P. Pandolfi, M. Roth, A. Karis, A. Karis, M. Leonard, E. Dzierzak, F. Grosveld, F. Grosveld, J. Engel, M. Lindenbaum, M. Lindenbaum (1995)
Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesisNature Genetics, 11
A. Minn, G. Gupta, P. Siegel, Paula Bos, Weiping Shu, D. Giri, A. Viale, A. Olshen, W. Gerald, J. Massagué (2005)
Genes that mediate breast cancer metastasis to lungNature, 436
Ko Tsutsui, Ri-ichiroh Manabe, Tomiko Yamada, Itsuko Nakano, Yasuko Oguri, D. Keene, G. Sengle, L. Sakai, K. Sekiguchi (2009)
ADAMTSL-6 Is a Novel Extracellular Matrix Protein That Binds to Fibrillin-1 and Promotes Fibrillin-1 Fibril Formation*The Journal of Biological Chemistry, 285
D. Grote, S. Boualia, A. Souabni, Calli Merkel, Xuan Chi, F. Costantini, Thomas Carroll, M. Bouchard (2008)
Gata3 Acts Downstream of β-Catenin Signaling to Prevent Ectopic Metanephric Kidney InductionPLoS Genetics, 4
Yan (2000)
CpG island arrays: An application toward deciphering epigenetic signatures of breast cancerClin Cancer Res, 6
R. Hendriks, M. Nawijn, J. Engel, Hikke Doorninck, F. Grosveld, A. Karis (1999)
Expression of the transcription factor GATA‐3 is required for the development of the earliest T cell progenitors and correlates with stages of cellular proliferation in the thymusEuropean Journal of Immunology, 29
Zhuoying Yang, L. Gu, P.-H. Romeo, D. Bories, H. Motohashi, Masayuki Yamamoto, J. Engel (1994)
Human GATA-3 trans-activation, DNA-binding, and nuclear localization activities are organized into distinct structural domainsMolecular and Cellular Biology, 14
A. Dydensborg, A. Rose, Brian Wilson, D. Grote, M. Paquet, V. Giguère, P. Siegel, M. Bouchard (2009)
GATA3 inhibits breast cancer growth and pulmonary breast cancer metastasisOncogene, 28
Sofia Gruvberger, M. Ringnér, Yidong Chen, Sujatha Panavally, L. Saal, Å. Borg, M. Fernö, Carsten Peterson, P. Meltzer (2001)
Estrogen receptor status in breast cancer is associated with remarkably distinct gene expression patterns.Cancer research, 61 16
J. Thiery (2002)
Epithelial–mesenchymal transitions in tumour progressionNature Reviews Cancer, 2
V. Popov, Kongming Wu, Jie Zhou, M. Powell, G. Mardon, Chenguang Wang, R. Pestell (2010)
The Dachshund gene in development and hormone-responsive tumorigenesisTrends in Endocrinology & Metabolism, 21
J. Chou, S. Provot, Z. Werb (2010)
GATA3 in development and cancer differentiation: Cells GATA have it!Journal of Cellular Physiology, 222
T. Abel, A. Michelson, Tom Maniatis (1993)
A Drosophila GATA family member that binds to Adh regulatory sequences is expressed in the developing fat body.Development, 119 3
K. Gaynor, I. Grigorieva, M. Nesbit, T. Cranston, T. Gomes, L. Gortner, R. Thakker (2009)
A missense GATA3 mutation, Thr272Ile, causes the hypoparathyroidism, deafness, and renal dysplasia syndrome.The Journal of clinical endocrinology and metabolism, 94 10
Asif Ali, P. Christie, I. Grigorieva, B. Harding, H. Esch, S. Ahmed, M. Bitner-Glindzicz, E. Blind, C. Bloch, P. Christin, P. Clayton, J. Gécz, B. Gilbert-Dussardier, E. Guillén-Navarro, A. Hackett, I. Halac, G. Hendy, F. Lalloo, C. Mache, Z. Mughal, A. Ong, C. Rinat, N. Shaw, S. Smithson, J. Tolmie, J. Weill, M. Nesbit, R. Thakker (2006)
Functional characterization of GATA3 mutations causing the hypoparathyroidism-deafness-renal (HDR) dysplasia syndrome: insight into mechanisms of DNA binding by the GATA3 transcription factor.Human molecular genetics, 16 3
T. Huang, P. Yan, M. Perry, D. Laux (1999)
CpG island arrays: an application toward deciphering epigenetic signatures of breast cancerNature Genetics, 23 Suppl 1
T. Jenssen, W. Kuo, W. Kuo, T. Stokke, E. Hovig (2002)
Associations between gene expressions in breast cancer and patient survivalHuman Genetics, 111
J. Doorninck, J. Wees, A. Karis, Erika Goedknegt, M. Coesmans, M. Rutteman, F. Grosveld, C. Zeeuw (1999)
GATA-3 Is Involved in the Development of Serotonergic Neurons in the Caudal Raphe NucleiThe Journal of Neuroscience, 19
J. Eeckhoute, E. Keeton, M. Lupien, Susan Krum, J. Carroll, Myles Brown (2007)
Positive Cross-Regulatory Loop Ties GATA-3 to Estrogen Receptor α Expression in Breast CancerCancer Research, 67
Aleksandra Adomas, Sara Grimm, C. Malone, Motoki Takaku, Jennifer Sims, P. Wade (2014)
Breast tumor specific mutation in GATA3 affects physiological mechanisms regulating transcription factor turnoverBMC Cancer, 14
GATA 3 mutations define a unique subtype of luminal - like breast
E. Lim, F. Vaillant, Di Wu, N. Forrest, B. Pal, A. Hart, M. Asselin-Labat, D. Gyorki, T. Ward, Audrey Partanen, F. Feleppa, L. Huschtscha, H. Thorne, S. Fox, M. Yan, J. French, Melissa Brown, G. Smyth, J. Visvader, G. Lindeman (2009)
Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriersNature Medicine, 15
C. Perou, T. Sørlie, M. Eisen, M. Rijn, S. Jeffrey, Christian Rees, J. Pollack, D. Ross, H. Johnsen, L. Akslen, Ø. Fluge, Alexander Pergamenschikov, Cheryl Williams, Shirley Zhu, P. Lønning, A. Børresen-Dale, P. Brown, D. Botstein (2000)
Molecular portraits of human breast tumoursNature, 406
N. Takemoto, K. Arai, S. Miyatake (2002)
Cutting Edge: The Differential Involvement of the N-Finger of GATA-3 in Chromatin Remodeling and Transactivation During Th2 DevelopmentThe Journal of Immunology, 169
J. Arnold, David Choong, E. Thompson, N. Waddell, G. Lindeman, J. Visvader, I. Campbell, G. Chenevix-Trench, kConFab (2008)
Frequent somatic mutations of GATA3 in non-BRCA1/BRCA2 familial breast tumors, but not in BRCA1-, BRCA2- or sporadic breast tumorsBreast Cancer Research and Treatment, 119
R. Yerushalmi, R. Woods, P. Ravdin, M. Hayes, K. Gelmon (2010)
Ki67 in breast cancer: prognostic and predictive potential.The Lancet. Oncology, 11 2
M. Shackleton, F. Vaillant, K. Simpson, J. Stingl, G. Smyth, M. Asselin-Labat, Li Wu, G. Lindeman, J. Visvader (2006)
Generation of a functional mammary gland from a single stem cellNature, 439
(2014)
with improved survival
M. Simon (1995)
Gotta have GATANature Genetics, 11
M. Ellis, L. Ding, D. Shen, Jingqin Luo, V. Suman, J. Wallis, B. Tine, J. Hoog, Reece Goiffon, Theodore Goldstein, S. Ng, Li Lin, R. Crowder, J. Snider, K. Ballman, J. Weber, Ken Chen, D. Koboldt, C. Kandoth, W. Schierding, Joshua McMichael, Christopher Miller, Charles Lu, C. Harris, M. McLellan, M. Wendl, K. Deschryver, D. Allred, L. Esserman, G. Unzeitig, J. Margenthaler, G. Babiera, P. Marcom, J. Guenther, M. Leitch, K. Hunt, J. Olson, Y. Tao, C. Maher, L. Fulton, R. Fulton, M. Harrison, Benjamin Oberkfell, Feiyu Du, Ryan Demeter, T. Vickery, A. Elhammali, H. Piwnica-Worms, Sandra McDonald, M. Watson, D. Dooling, D. Ota, Li-Wei Chang, R. Bose, T. Ley, D. Piwnica-Worms, Joshua Stuart, R. Wilson, E. Mardis (2012)
Whole Genome Analysis Informs Breast Cancer Response to Aromatase InhibitionNature, 486
D. Voduc, M. Cheang, T. Nielsen (2008)
GATA-3 Expression in Breast Cancer Has a Strong Association with Estrogen Receptor but Lacks Independent Prognostic ValueCancer Epidemiology Biomarkers & Prevention, 17
B. Weigelt, A. Glas, L. Wessels, A. Witteveen, J. Peterse, L. Veer (2003)
Gene expression profiles of primary breast tumors maintained in distant metastasesProceedings of the National Academy of Sciences of the United States of America, 100
J. Furusawa, K. Moro, Y. Motomura, Kazuo Okamoto, Jinfang Zhu, H. Takayanagi, M. Kubo, S. Koyasu (2013)
Critical Role of p38 and GATA3 in Natural Helper Cell FunctionThe Journal of Immunology, 191
Q. Tong, G. Dalgin, Haiyan Xu, C. Ting, J. Leiden, G. Hotamisligil (2000)
Function of GATA transcription factors in preadipocyte-adipocyte transition.Science, 290 5489
Yizhou Jiang, Keda Yu, W. Zuo, Wen-Ting Peng, Z. Shao (2014)
GATA3 mutations define a unique subtype of luminal‐like breast cancer with improved survivalCancer, 120
T. Sørlie, R. Tibshirani, Joel Parker, T. Hastie, J. Marron, A. Nobel, Shibing Deng, H. Johnsen, Robert Pesich, S. Geisler, J. Demeter, C. Perou, P. Lønning, P. Brown, A. Børresen-Dale, D. Botstein (2003)
Repeated observation of breast tumor subtypes in independent gene expression data setsProceedings of the National Academy of Sciences of the United States of America, 100
A. Nesbit, M. Bowl, B. Harding, Asif Ali, Alejandro Ayala, C. Crowe, A. Dobbie, G. Hampson, I. Holdaway, M. Levine, R. McWilliams, S. Rigden, J. Sampson, A. Williams, R. Thakker (2002)
Characterization of GATA3 Mutations in the Hypoparathyroidism, Deafness, and Renal Dysplasia (HDR) Syndrome*Journal of Biological Chemistry, 279
de Rijn (2002)
Expression of cytokeratins 17 and 5 identifies a group of breast carcinomas with poor clinical outcomeAm J Pathol, 161
K. Wagner, T. Ward, B. Davis, R. Wiseman, L. Hennighausen (2001)
Spatial and temporal expression of the Cre gene under the control of the MMTV-LTR in different lines of transgenic miceTransgenic Research, 10
M. West, C. Blanchette, H. Dressman, Erich Huang, Seiichi Ishida, R. Spang, H. Zuzan, J. Olson, J. Marks, J. Nevins (2001)
Predicting the clinical status of human breast cancer by using gene expression profilesProceedings of the National Academy of Sciences of the United States of America, 98
E. Putz, K. Witter, S. Offner, P. Stosiek, A. Zippelius, Judith Johnson, R. Zahn, G. Riethmüller, K. Pantel (1999)
Phenotypic characteristics of cell lines derived from disseminated cancer cells in bone marrow of patients with solid epithelial tumors: establishment of working models for human micrometastases.Cancer research, 59 1
(2006)
fate in the mammary gland
Jerry Usary, V. Llaca, G. Karaca, Shafaq Presswala, M. Karaca, Xiaping He, A. Langerød, R. Kåresen, D. Oh, L. Dressler, P. Lønning, R. Strausberg, S. Chanock, A. Børresen-Dale, C. Perou (2004)
Mutation of GATA3 in human breast tumorsOncogene, 23
M. Labastie, D. Bories, C. Chabret, J. Gregoire, S. Chrétien, P. Romeo (1994)
Structure and expression of the human GATA3 gene.Genomics, 21 1
S. Chanock, L. Burdett, M. Yeager, V. Llaca, A. Langerød, Shafaq Presswalla, R. Kaaresen, R. Strausberg, D. Gerhard, V. Kristensen, C. Perou, A. Børresen-Dale (2007)
Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomasBreast Cancer Research, 9
L. Veer, H. Dai, M. Vijver, Yudong He, A. Hart, M. Mao, H. Peterse, K. Kooy, M. Marton, A. Witteveen, G. Schreiber, R. Kerkhoven, C. Roberts, P. Linsley, R. Bernards, S. Friend (2002)
Gene expression profiling predicts clinical outcome of breast cancerNature, 415
Franco Izzo, Florencia Mercogliano, L. Venturutti, M. Tkach, Gloria Inurrigarro, R. Schillaci, L. Cerchietti, P. Elizalde, Cecilia Proietti (2014)
Progesterone receptor activation downregulates GATA3 by transcriptional repression and increased protein turnover promoting breast tumor growthBreast Cancer Research : BCR, 16
J. Eeckhoute, E. Keeton, M. Lupien, Susan Krum, J. Carroll, Myles Brown (2007)
Positive cross-regulatory loop ties GATA-3 to estrogen receptor alpha expression in breast cancer.Cancer research, 67 13
M. Lacroix, G. Leclercq (2004)
About GATA3, HNF3A, and XBP1, three genes co-expressed with the oestrogen receptor-α gene (ESR1) in breast cancerMolecular and Cellular Endocrinology, 219
C. Evans, Richard Jenner (2013)
Transcription factor interplay in T helper cell differentiationBriefings in Functional Genomics, 12
(1996)
common to vertebrates and Drosophila
M. Asselin-Labat, K. Sutherland, F. Vaillant, D. Gyorki, Di Wu, Sheridan Holroyd, K. Breslin, T. Ward, Wei Shi, M. Bath, S. Deb, S. Fox, G. Smyth, G. Lindeman, J. Visvader (2011)
Gata-3 Negatively Regulates the Tumor-Initiating Capacity of Mammary Luminal Progenitor Cells and Targets the Putative Tumor Suppressor Caspase-14Molecular and Cellular Biology, 31
GATA3 is a critical transcription factor in the development of various human systems. The notion that GATA3 expression is required for the differentiation and maintenance of normal breast tissue has been well established. Recently, GATA3 is found to actively participate in the multistep process leading breast cancer pathogenesis, including tumorigenesis, tumor differentiation, epithelial mesenchymal transition, and metastasis through regulation of various target genes. On the other hand, several studies have raised questions and highlighted the role of GATA3‐low or GATA3‐negative cells during the malignant development of breast cancer. In addition to gene expression, GATA3 mutations provide another dimension of complexity. As one of the most frequently mutated genes in breast cancer, GATA3 mutations may have an effect on DNA‐binding ability, protein production, and transactivation activity. Recognition of the multiple function of GATA3 in breast cancer will serve to deepen our understanding of the nature of this disease and develop novel therapeutic approaches.
Medicinal Research Reviews – Wiley
Published: Nov 1, 2015
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