Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

The role of the endocannabinoid system in addictive behavior

The role of the endocannabinoid system in addictive behavior The revolution on cannabinoid research started when the primary psychoactive constituents of cannabis, Δ 8 ‐THC and Δ 9 ‐THC, were isolated in 1964 (Gaoni & Mechoulam ). This finding triggered the identification (Devane et al . ; Herkenham et al . ) and cloning (Matsuda et al . ) of its cellular target, the cannabinoid receptor (CB1), and a second mainly peripheral CB2 receptor (Munro, Thomas & Abu‐Shaar ). The next cornerstone in cannabinoid research was the identification of natural ligands for the CB1 receptor: arachidonoylethanolamide, named anandamide from the Sanskrit ‘internal bliss’ (Devane et al . ), and 2‐arachidonoylglycerol (Mechoulam et al . ; Sugiura et al . ). The complete picture of the endocannabinoid system (ECS) was achieved with the description of a biochemical pathway for the synthesis, release (Di Marzo et al . ; Cadas et al . ), transport (Beltramo et al . ) and degradation (Cravatt et al . ) of the endocannabinoids. The relevance of this system in the organism is extensive and involves not only the central nervous system, affecting memory, cognitive and mood processes, but also the autonomic, immune and reproductive system, the endocrine network and the gastrointestinal tract http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Addiction Biology Wiley

The role of the endocannabinoid system in addictive behavior

Bilbao, Ainhoa
Addiction Biology , Volume 18 (6) – Nov 1, 2013
Download PDF
4 pages

Loading next page...
 
/lp/wiley/the-role-of-the-endocannabinoid-system-in-addictive-behavior-sz0Y2tLDhU
Publisher
Wiley
Copyright
© 2013 Society for the Study of Addiction
ISSN
1355-6215
eISSN
1369-1600
DOI
10.1111/adb.12115
pmid
24283981
Publisher site
See Article on Publisher Site

Abstract

The revolution on cannabinoid research started when the primary psychoactive constituents of cannabis, Δ 8 ‐THC and Δ 9 ‐THC, were isolated in 1964 (Gaoni & Mechoulam ). This finding triggered the identification (Devane et al . ; Herkenham et al . ) and cloning (Matsuda et al . ) of its cellular target, the cannabinoid receptor (CB1), and a second mainly peripheral CB2 receptor (Munro, Thomas & Abu‐Shaar ). The next cornerstone in cannabinoid research was the identification of natural ligands for the CB1 receptor: arachidonoylethanolamide, named anandamide from the Sanskrit ‘internal bliss’ (Devane et al . ), and 2‐arachidonoylglycerol (Mechoulam et al . ; Sugiura et al . ). The complete picture of the endocannabinoid system (ECS) was achieved with the description of a biochemical pathway for the synthesis, release (Di Marzo et al . ; Cadas et al . ), transport (Beltramo et al . ) and degradation (Cravatt et al . ) of the endocannabinoids. The relevance of this system in the organism is extensive and involves not only the central nervous system, affecting memory, cognitive and mood processes, but also the autonomic, immune and reproductive system, the endocrine network and the gastrointestinal tract

Journal

Addiction Biology – Wiley

Published: Nov 1, 2013

References

  • A genome‐wide association study of DSM‐IV cannabis dependence
    Agrawal, A; Lynskey, MT; Hinrichs, A; Grucza, R; Saccone, SF; Krueger, R; Neuman, R; Howells, W; Fisher, S; Fox, L; Cloninger, R; Dick, DM; Doheny, KF; Edenberg, HJ; Goate, AM; Hesselbrock, V; Johnson, E; Kramer, J; Kuperman, S; Nurnberger, JI; Pugh, E; Schuckit, M; Tischfield, J; Rice, JP; Bucholz, KK; Bierut, LJ
  • Functional role of high‐affinity anandamide transport, as revealed by selective inhibition
    Beltramo, M; Stella, N; Calignano, A; Lin, SY; Makriyannis, A; Piomelli, D
  • CNR1 gene polymorphisms in addictive disorders: a systematic review and a meta‐analysis
    Benyamina, A; Kebir, O; Blecha, L; Reynaud, M; Krebs, MO
  • Advanced transgenic approaches to understand alcohol‐related phenotypes in animals
    Bilbao, A
  • Biosynthesis of an endogenous cannabinoid precursor in neurons and its control by calcium and cAMP
    Cadas, H; Gaillet, S; Beltramo, M; Venance, L; Piomelli, D
  • A human laboratory study investigating the effects of quetiapine on marijuana withdrawal and relapse in daily marijuana smokers
    Cooper, ZD; Foltin, RW; Hart, CL; Vosburg, SK; Comer, SD; Haney, M
  • Individual differences in decision making and reward processing predict changes in cannabis use: a prospective functional magnetic resonance imaging study
    Cousijn, J; Wiers, RW; Ridderinkhof, KR; Brink, W; Veltman, DJ; Porrino, LJ; Goudriaan, AE
  • Molecular characterization of an enzyme that degrades neuromodulatory fatty‐acid amides
    Cravatt, BF; Giang, DK; Mayfield, SP; Boger, DL; Lerner, RA; Gilula, NB
  • Cannabinoid‐1 receptor antagonist rimonabant (SR141716) increases striatal dopamine D2 receptor availability
    Crunelle, CL; Giessen, E; Schulz, S; Vanderschuren, LJ; Bruin, K; Brink, W; Booij, J
  • Determination and characterization of a cannabinoid receptor in rat brain
    Devane, WA; Dysarz, FA; Johnson, M; Melvin, LS; Howlett, AC
  • Isolation and structure of a brain constituent that binds to the cannabinoid receptor
    Devane, WA; Hanus, L; Breuer, A; Pertwee, RG; Stevenson, LA; Griffin, G; Gibson, D; Mandelbaum, A; Etinger, A; Mechoulam, R
  • Formation and inactivation of endogenous cannabinoid anandamide in central neurons
    Di Marzo, V; Fontana, A; Cadas, H; Schinelli, S; Cimino, G; Schwartz, JC; Piomelli, D
  • Endocannabinoids: endogenous cannabinoid receptor ligands with neuromodulatory action
    Di Marzo, V; Melck, D; Bisogno, T; De Petrocellis, L
  • Diminished error‐related brain activity as a promising endophenotype for substance‐use disorders: evidence from high‐risk offspring
    Euser, AS; Evans, BE; Greaves‐Lord, K; Huizink, AC; Franken, IH
  • Residual learning deficit after heavy exposure to cannabis or alcohol in rats
    Fehr, KA; Kalant, H; LeBlanc, AE
  • Cannabinoid receptor stimulation increases motivation for nicotine and nicotine seeking
    Gamaleddin, I; Wertheim, C; Zhu, AZ; Coen, KM; Vemuri, K; Makryannis, A; Goldberg, SR; Le Foll, B
  • Isolation, structure and partial synthesis of an active constituent of hashish
    Gaoni, Y; Mechoulam, R
  • Publication trends in addiction research
    Helinski, S; Spanagel, R
  • Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study
    Herkenham, M; Lynn, AB; Johnson, MR; Melvin, LS; Costa, BR; Rice, KC
  • Reinforcing and neurochemical effects of cannabinoid CB1 receptor agonists, but not cocaine, are altered by an adenosine A2A receptor antagonist
    Justinová, Z; Ferré, S; Redhi, GH; Mascia, P; Stroik, J; Quarta, D; Yasar, S; Müller, CE; Franco, R; Goldberg, SR
  • Protracted abstinence from distinct drugs of abuse shows regulation of a common gene network
    Le Merrer, J; Befort, K; Gardon, O; Filliol, D; Darcq, E; Dembele, D; Becker, JA; Kieffer, BL
  • Striatal and extrastriatal dopamine transporter in cannabis and tobacco addiction: a high‐resolution PET study
    Leroy, C; Karila, L; Martinot, JL; Lukasiewicz, M; Duchesnay, E; Comtat, C; Dollé, F; Benyamina, A; Artiges, E; Ribeiro, MJ; Reynaud, M; Trichard, C
  • Sex‐dependent effects of maternal deprivation and adolescent cannabinoid treatment on adult rat behavior
    Llorente‐Berzal, A; Fuentes, S; Gagliano, H; López‐Gallardo, M; Armario, A; Viveros, MP; Nadal, R
  • Structure of a cannabinoid receptor and functional expression of the cloned cDNA
    Matsuda, LA; Lolait, SJ; Brownstein, MJ; Young, AC; Bonner, TI
  • Evolutionary origins of the endocannabinoid system
    McPartland, J; Matias, I; Di Marzo, V; Glass, M
  • The endocannabinoid system modulates the valence of the emotion associated to food ingestion
    Méndez‐Díaz, M; Rueda‐Orozco, PE; Ruiz‐Contreras, AE; Prospéro‐García, O
  • Identification of an endogenous 2‐monoglyceride, present in canine gut, that binds to cannabinoid receptors
    Mechoulam, R; Ben‐Shabat, S; Hanus, L; Ligumsky, M; Kamisnki, NE; Schatz, AR; Gopher, A; Almog, S; Martin, BR; Compton, DR
  • Molecular characterization of a peripheral receptor for cannabinoids
    Munro, S; Thomas, KL; Abu‐Shaar, M
  • Puberty as a highly vulnerable developmental period for the consequences of cannabis exposure
    Schneider, M
  • Nicotine reinforcement is reduced by cannabinoid CB1 receptor blockade in the ventral tegmental area
    Simonnet, A; Cador, M; Caille, S
  • Pharmacogenetics of alcohol, nicotine and drug addiction treatments
    Sturgess, JE; George, TP; Kennedy, JL; Heinz, A; Müller, DJ
  • 2‐Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain
    Sugiura, T; Kondo, S; Sukagawa, A; Nakane, S; Shinoda, A; Itoh, K; Yamashita, A; Waku, K
  • Pharmacotherapy for cannabis dependence: how close are we?
    Vandrey, R; Haney, M
  • No association of candidate genes with cannabis use in a large sample of Australian twin families
    Verweij, KJ; Zietsch, BP; Liu, JZ; Medland, SE; Lynskey, MT; Madden, PA; Agrawal, A; Montgomery, GW; Heath, AC; Martin, NG
  • Innate difference in the endocannabinoid signaling and its modulation by alcohol consumption in alcohol‐preferring sP rats
    Vinod, KY; Maccioni, P; Garcia‐Gutierrez, MS; Femenia, T; Xie, S; Carai, MA; Manzanares, J; Cooper, TB; Hungund, BL; Colombo, G
  • Long‐term behavioral and pharmacodynamic effects of delta‐9‐tetrahydrocannabinol in female rats depend on ovarian hormone status
    Winsauer, PJ; Daniel, JM; Filipeanu, CM; Leonard, ST; Hulst, JL; Rodgers, SP; Lassen‐Greene, CL; Sutton, JL