The role of the endocannabinoid system in addictive behavior

The role of the endocannabinoid system in addictive behavior The revolution on cannabinoid research started when the primary psychoactive constituents of cannabis, Δ 8 ‐THC and Δ 9 ‐THC, were isolated in 1964 (Gaoni & Mechoulam ). This finding triggered the identification (Devane et al . ; Herkenham et al . ) and cloning (Matsuda et al . ) of its cellular target, the cannabinoid receptor (CB1), and a second mainly peripheral CB2 receptor (Munro, Thomas & Abu‐Shaar ). The next cornerstone in cannabinoid research was the identification of natural ligands for the CB1 receptor: arachidonoylethanolamide, named anandamide from the Sanskrit ‘internal bliss’ (Devane et al . ), and 2‐arachidonoylglycerol (Mechoulam et al . ; Sugiura et al . ). The complete picture of the endocannabinoid system (ECS) was achieved with the description of a biochemical pathway for the synthesis, release (Di Marzo et al . ; Cadas et al . ), transport (Beltramo et al . ) and degradation (Cravatt et al . ) of the endocannabinoids. The relevance of this system in the organism is extensive and involves not only the central nervous system, affecting memory, cognitive and mood processes, but also the autonomic, immune and reproductive system, the endocrine network and the gastrointestinal tract http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Addiction Biology Wiley

The role of the endocannabinoid system in addictive behavior

Addiction Biology, Volume 18 (6) – Nov 1, 2013

Loading next page...
 
/lp/wiley/the-role-of-the-endocannabinoid-system-in-addictive-behavior-sz0Y2tLDhU
Publisher
Wiley
Copyright
© 2013 Society for the Study of Addiction
ISSN
1355-6215
eISSN
1369-1600
DOI
10.1111/adb.12115
pmid
24283981
Publisher site
See Article on Publisher Site

Abstract

The revolution on cannabinoid research started when the primary psychoactive constituents of cannabis, Δ 8 ‐THC and Δ 9 ‐THC, were isolated in 1964 (Gaoni & Mechoulam ). This finding triggered the identification (Devane et al . ; Herkenham et al . ) and cloning (Matsuda et al . ) of its cellular target, the cannabinoid receptor (CB1), and a second mainly peripheral CB2 receptor (Munro, Thomas & Abu‐Shaar ). The next cornerstone in cannabinoid research was the identification of natural ligands for the CB1 receptor: arachidonoylethanolamide, named anandamide from the Sanskrit ‘internal bliss’ (Devane et al . ), and 2‐arachidonoylglycerol (Mechoulam et al . ; Sugiura et al . ). The complete picture of the endocannabinoid system (ECS) was achieved with the description of a biochemical pathway for the synthesis, release (Di Marzo et al . ; Cadas et al . ), transport (Beltramo et al . ) and degradation (Cravatt et al . ) of the endocannabinoids. The relevance of this system in the organism is extensive and involves not only the central nervous system, affecting memory, cognitive and mood processes, but also the autonomic, immune and reproductive system, the endocrine network and the gastrointestinal tract

Journal

Addiction BiologyWiley

Published: Nov 1, 2013

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off