The role of the adrenal gland in cytoprotection against stress‐induced gastric ulcers in rats

The role of the adrenal gland in cytoprotection against stress‐induced gastric ulcers in rats Subcutaneous treatment with either prednisone or isoproterenol significantly prevented the development of cold plus restraint stress (CRS)‐induced gastric ulcers in rats. The effect of each agent was dose‐dependent. Bilateral adrenalectomy prevented isoproterenol, but not prednisone‐induced gastric cytoprotection. However, prednisone (1 mg/kg × 5 days) restored the ability of isoproterenol to afford cytoprotection in adrenalectomized rats. Finally, inhibition of prostaglandin synthesis with indomethacin (5 mg/kg) totally abolished the cytoprotective response to both prednisone and isoproterenol in this CRS model. These results indicate that glucocorticoids modulate the cytoprotective effect of adrenal catecholamines, and that both adrenal glucocorticoids and catecholamines require an intact prostaglandin synthetic pathway for expression of their cytoprotective properties. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neuroscience Research Wiley

The role of the adrenal gland in cytoprotection against stress‐induced gastric ulcers in rats

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Publisher
Wiley
Copyright
Copyright © 1984 Alan R. Liss, Inc.
ISSN
0360-4012
eISSN
1097-4547
DOI
10.1002/jnr.490110209
pmid
6708137
Publisher site
See Article on Publisher Site

Abstract

Subcutaneous treatment with either prednisone or isoproterenol significantly prevented the development of cold plus restraint stress (CRS)‐induced gastric ulcers in rats. The effect of each agent was dose‐dependent. Bilateral adrenalectomy prevented isoproterenol, but not prednisone‐induced gastric cytoprotection. However, prednisone (1 mg/kg × 5 days) restored the ability of isoproterenol to afford cytoprotection in adrenalectomized rats. Finally, inhibition of prostaglandin synthesis with indomethacin (5 mg/kg) totally abolished the cytoprotective response to both prednisone and isoproterenol in this CRS model. These results indicate that glucocorticoids modulate the cytoprotective effect of adrenal catecholamines, and that both adrenal glucocorticoids and catecholamines require an intact prostaglandin synthetic pathway for expression of their cytoprotective properties.

Journal

Journal of Neuroscience ResearchWiley

Published: Jan 1, 1984

References

  • Noradrenaline release in rats during prolonged cold‐stress and repeated swim stress
    Benedict, Benedict; Fillenz, Fillenz; Standford, Standford
  • Cytoprotective effect of centrally administered neurotensin on stress‐induced gastric ulcers
    Nemeroff, Nemeroff; Hernandez, Hernandez; Orlando, Orlando; Prange, Prange

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