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The role of cannabinoids in adult neurogenesis

The role of cannabinoids in adult neurogenesis The processes underpinning post‐developmental neurogenesis in the mammalian brain continue to be defined. Such processes involve the proliferation of neural stem cells and neural progenitor cells (NPCs), neuronal migration, differentiation and integration into a network of functional synapses within the brain. Both intrinsic (cell signalling cascades) and extrinsic (neurotrophins, neurotransmitters, cytokines, hormones) signalling molecules are intimately associated with adult neurogenesis and largely dictate the proliferative activity and differentiation capacity of neural cells. Cannabinoids are a unique class of chemical compounds incorporating plant‐derived cannabinoids (the active components of Cannabis sativa), the endogenous cannabinoids and synthetic cannabinoid ligands, and these compounds are becoming increasingly recognized for their roles in neural developmental processes. Indeed, cannabinoids have clear modulatory roles in adult neurogenesis, probably through activation of both CB1 and CB2 receptors. In recent years, a large body of literature has deciphered the signalling networks involved in cannabinoid‐mediated regulation of neurogenesis. This timely review summarizes the evidence that the cannabinoid system is intricately associated with neuronal differentiation and maturation of NPCs and highlights intrinsic/extrinsic signalling mechanisms that are cannabinoid targets. Overall, these findings identify the central role of the cannabinoid system in adult neurogenesis in the hippocampus and the lateral ventricles and hence provide insight into the processes underlying post‐developmental neurogenesis in the mammalian brain. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png British Journal of Pharmacology Wiley

The role of cannabinoids in adult neurogenesis

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Publisher
Wiley
Copyright
Copyright © 2015 The British Pharmacological Society
ISSN
0007-1188
eISSN
1476-5381
DOI
10.1111/bph.13186
pmid
25951750
Publisher site
See Article on Publisher Site

Abstract

The processes underpinning post‐developmental neurogenesis in the mammalian brain continue to be defined. Such processes involve the proliferation of neural stem cells and neural progenitor cells (NPCs), neuronal migration, differentiation and integration into a network of functional synapses within the brain. Both intrinsic (cell signalling cascades) and extrinsic (neurotrophins, neurotransmitters, cytokines, hormones) signalling molecules are intimately associated with adult neurogenesis and largely dictate the proliferative activity and differentiation capacity of neural cells. Cannabinoids are a unique class of chemical compounds incorporating plant‐derived cannabinoids (the active components of Cannabis sativa), the endogenous cannabinoids and synthetic cannabinoid ligands, and these compounds are becoming increasingly recognized for their roles in neural developmental processes. Indeed, cannabinoids have clear modulatory roles in adult neurogenesis, probably through activation of both CB1 and CB2 receptors. In recent years, a large body of literature has deciphered the signalling networks involved in cannabinoid‐mediated regulation of neurogenesis. This timely review summarizes the evidence that the cannabinoid system is intricately associated with neuronal differentiation and maturation of NPCs and highlights intrinsic/extrinsic signalling mechanisms that are cannabinoid targets. Overall, these findings identify the central role of the cannabinoid system in adult neurogenesis in the hippocampus and the lateral ventricles and hence provide insight into the processes underlying post‐developmental neurogenesis in the mammalian brain.

Journal

British Journal of Pharmacology – Wiley

Published: Aug 1, 2015

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  • The endocannabinoid anandamide inhibits neuronal progenitor cell differentiation through attenuation of the Rap1/B‐Raf/ERK pathway
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    Sanai, Sanai; Tramontin, Tramontin; Quinones‐Hinojosa, Quinones‐Hinojosa; Barbaro, Barbaro; Gupta, Gupta; Kunwar, Kunwar
  • Direct stimulation of adult neural stem cells in vitro and neurogenesis in vivo by vascular endothelial growth factor
    Schanzer, Schanzer; Wachs, Wachs; Wilhelm, Wilhelm; Acker, Acker; Cooper‐Kuhn, Cooper‐Kuhn; Beck, Beck
  • Increased neurogenesis and the ectopic granule cells after intrahippocampal BDNF infusion in adult rats
    Scharfman, Scharfman; Goodman, Goodman; Macleod, Macleod; Phani, Phani; Antonelli, Antonelli; Croll, Croll
  • Stress, stress hormones, and adult neurogenesis
    Schoenfeld, Schoenfeld; Gould, Gould
  • The effect of cannabichromene on adult neural stem/progenitor cells
    Shinjyo, Shinjyo; Di Marzo, Di Marzo
  • Regulation of neural progenitor cell fate by anandamide
    Soltys, Soltys; Yushak, Yushak; Mao‐Draayer, Mao‐Draayer
  • Fascin regulates the migration of subventricular zone‐derived neuroblasts in the postnatal brain
    Sonego, Sonego; Gajendra, Gajendra; Parsons, Parsons; Ma, Ma; Hobbs, Hobbs; Zentar, Zentar
  • Dual synthetic pathways of N‐arachidonoylethanolamine (anandamide) – an endogenous cannabinoid receptor ligand in rat‐brain
    Sugiura, Sugiura; Sukagawa, Sukagawa; Kondo, Kondo; Yamashita, Yamashita; Waku, Waku
  • In vivo fate analysis reveals the multipotent and self‐renewal capacities of Sox2+ neural stem cells in the adult hippocampus
    Suh, Suh; Consiglio, Consiglio; Ray, Ray; Sawai, Sawai; D'Amour, D'Amour; Gage, Gage
  • Signaling in adult neurogenesis
    Suh, Suh; Deng, Deng; Gage, Gage
  • The molecular basis of the cooperation between EGF, FGF and eCB receptors in the regulation of neural stem cell function
    Sutterlin, Sutterlin; Williams, Williams; Chambers, Chambers; Saraf, Saraf; Schack, Schack; Reisenberg, Reisenberg
  • Knockdown of brain‐derived neurotrophic factor in specific brain sites precipitates behaviors associated with depression and reduces neurogenesis
    Taliaz, Taliaz; Stall, Stall; Dar, Dar; Zangen, Zangen
  • Expression of angiogenic and neurotrophic factors in the progenitor cell niche of adult monkey subventricular zone
    Tonchev, Tonchev; Yamashima, Yamashima; Guo, Guo; Chaldakov, Chaldakov; Takakura, Takakura
  • Neurons born in the adult dentate gyrus form functional synapses with target cells
    Toni, Toni; Laplagne, Laplagne; Zhao, Zhao; Lombardi, Lombardi; Ribak, Ribak; Gage, Gage
  • Regional distribution of Sonic Hedgehog, patched, and smoothened mRNA in the adult rat brain
    Traiffort, Traiffort; Charytoniuk, Charytoniuk; Faure, Faure; Ruat, Ruat
  • Induction of neurogenesis in the adult rat subventricular zone and neostriatum following dopamine D3 receptor stimulation
    Van Kampen, Van Kampen; Hagg, Hagg; Robertson, Robertson
  • Activation of CB1 inhibits NGF‐induced sensitization of TRPV1 in adult mouse afferent neurons
    Wang, Wang; McDowell, McDowell; Wang, Wang; Alvarez, Alvarez; Gomez, Gomez; Bjorling, Bjorling
  • The FGF receptor uses the endocannabinoid signaling system to couple to an axonal growth response
    Williams, Williams; Walsh, Walsh; Doherty, Doherty
  • Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses
    Wilson, Wilson; Nicoll, Nicoll
  • Cannabinoid receptor CB1 mediates baseline and activity‐induced survival of new neurons in adult hippocampal neurogenesis
    Wolf, Wolf; Bick‐Sander, Bick‐Sander; Fabel, Fabel; Leal‐Galicia, Leal‐Galicia; Tauber, Tauber; Ramirez‐Rodriguez, Ramirez‐Rodriguez
  • Tumor necrosis factor‐alpha modulates the proliferation of neural progenitors in the subventricular/ventricular zone of adult rat brain
    Wu, Wu; Kuo, Kuo; Liu, Liu; Tzeng, Tzeng
  • Activation of type 1 cannabinoid receptor (CB1R) promotes neurogenesis in murine subventricular zone cell cultures
    Xapelli, Xapelli; Agasse, Agasse; Sarda‐Arroyo, Sarda‐Arroyo; Bernardino, Bernardino; Santos, Santos; Ribeiro, Ribeiro
  • Modulation of subventricular zone oligodendrogenesis: a role for hemopressin?
    Xapelli, Xapelli; Agasse, Agasse; Grade, Grade; Bernardino, Bernardino; Ribeiro, Ribeiro; Schitine, Schitine
  • A role for adult TLX‐positive neural stem cells in learning and behaviour
    Zhang, Zhang; Zou, Zou; He, He; Gage, Gage; Evans, Evans
  • Fibroblast growth factor receptor‐1 is required for long‐term potentiation, memory consolidation, and neurogenesis
    Zhao, Zhao; Li, Li; Shimazu, Shimazu; Zhou, Zhou; Lu, Lu; Deng, Deng