SHORT COMMUNICATION The relevance of both plasma free tryptophan and insulin to rat brain tryptophan concentration (Received 6 February 1976. Accepted 20 March 1976) THECONTROL of brain tryptophan concentration is of par- ice and stored at -20Â°C. Plasma unesterified fatty acids ticular importance because tryptophan hydroxylase, the (UFA) were determined fluorimetrically (Curzon and Kanrate limiting enzyme for brain 5-hydroxytryptamine (5-HT) tamaneni, to be published) and plasma free and total trypsynthesis is normally unsaturated with tryptophan (FRIED- tophan and tyrosine and brain tryptophan and tyrosine MAN et al., 1972) so that alteration of brain tryptophan er were determined as previously described (CURZON al., & 1972). concentration leads to altered brain 5-HT turnover. There- 1972; KNOTT CURZON, Phenylalanine was determined by a fluorimetric ninhydfore, much attention has been paid to two possible in& 1962) in plasma and fluences on the accessibility of plasma tryptophan to the rin method (MCCAMAN ROBINS, in separate 50 pl samples of the brain extract used for the rat brain. (1) The concentration of plasma free tryptophan (KNOTT tyrosine estimation. Plasma insulin was determined by & CURZON, 1972; TAGLIAMONTEul., 1973) which rises radio-immunoassay (Kit method, Lepetit Ltd., Maidenet in many circumstances in which plasma unesterified fatty
Journal of Neurochemistry – Wiley
Published: Jul 1, 1976
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