1 Dorsal roots (L3‐L7) isolated from immature (1–9 day old) rats were depolarized selectively by kainate (1–100 μM). L‐Glutamate (25–1000 μM), but not L‐aspartate, mimicked the action of kainate. N‐methylaspartate had no activity on these preparations and quisqualate was thirty times less active than kainate. 2 Depolarizations evoked by L‐glutamate (100–1000 μM) faded rapidly in the presence of L‐glutamate. Depolarizations evoked by kainate were depressed during the fade induced by L‐glutamate. 3 Certain electrically evoked C‐fibre volleys in dorsal roots or leg nerves of rats at any age were selectively depressed or abolished in the presence of kainate. The effect of kainate was more selective than that of γ‐aminobutyric acid or capsaicin. 4 Prolonged treatment of dorsal roots with kainate did not appear to be deleterious to C‐fibres. 5 It is suggested that certain primary afferent C‐fibres possess kainate receptors which may be activated physiologically by L‐glutamate released at their central terminations.
British Journal of Pharmacology – Wiley
Published: Feb 1, 1986
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