INTRODUCTIONThe thalassemias (thals) are a group of inherited hemoglobic disorders resulting from defects in the synthesis of one or more of the hemoglobin chains. According to the type of globin involved, thalassemia can be divided into α‐, β‐, δβ‐thal and hereditay persistence of fetal haemoglobin (HPFH). Two types of the determinants for δβ‐thal or HPFH, namely, the deletional and nondeletional types, have been classified on the basis of extensive molecular studies. (δβ)0‐thal and HPFH are caused by large deletions in the β‐globin cluster involving δ‐ and β‐globin genes, with or without Aγ‐globin genes. These mutations are characterized by high fetal haemoglobin (Hb F) levels in adult. Heterozygotes for δβ‐thal have hypochromic microcytic red cells with the levels of Hb F ranging from 5% to 20%, and, in contrast, HPFH heterozygotes have normal blood indices with higher Hb F (15%‐30%). Homozygotes for (δβ)0‐thal and compound heterozyotes for (δβ)0‐thal with β‐thal usually lead to a clinical phenotype of thal intermedia or major. Though, HPFH homozygotes are clinically asymptomatic, compound heterozyotes for HPFH with β‐thal express the phenotype thal intermedia. Furthermore, there are different types of (δβ)0‐thal or HPFH deletions have been reported in different ethnic groups and different regions. Therefore, well‐known
Journal of Clinical Laboratory Analysis – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ;
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera